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- W73462660 abstract "To reach cancer cells in a tumor, a blood-borne molecule must make its way into the blood vessels of the tumor and across the vessel wall into the interstitium, and finally migrate through the interstitium. Unfortunately, tumors often develop in ways that hinder each of these steps. Our research goals are to analyze each of these steps experimentally and theoretically, and then integrate the resulting information in a unified theoretical framework. Oxygen, one of the smallest blood-borne molecular species, is potentially the most important enhancer of cancer radiation treatment. Its arrival to the needed sites potentially is determined by the unique transport characteristics of the tumor microcirculation. Thus, our analysis and synthesis approach allows us to obtain a better understanding of physiological barriers in solid tumors and to develop novel strategies to exploit and/or overcome these barriers for improved cancer treatment." @default.
- W73462660 created "2016-06-24" @default.
- W73462660 creator A5015585176 @default.
- W73462660 date "1997-01-01" @default.
- W73462660 modified "2023-09-27" @default.
- W73462660 title "Tumor Microcirculation: Role in Drug and Nutrient Delivery" @default.
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- W73462660 doi "https://doi.org/10.1007/978-1-4612-1976-7_4" @default.
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