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- W73470962 abstract "Antibody responses to the majority of multi-determinant antigens appear to depend on interactions between at least three functionally distinct cell types, thymus-derived lymphocytes (T cells), non-thymus-derived lymphocytes (B cells), and accessory cells referred to collectively but somewhat loosely as adherent cells or macrophages. The macrophage or adherent cell has assumed an increasingly important role over the past few years in both induction and expression of the immune response. Macrophages, though nonspecific in an immunological sense, possess properties that enable them to have a profound effect on the interaction between T cells and B cells. This chapter discusses the properties that are relevant to an analysis of the mechanisms of macrophage collaboration. The function of macrophages taken from different sources varies significantly. The term, adherent cells, is frequently used synonymously with macrophages but it is known that lymphocytes, particularly some B cells and activated T cells, can stick to glass or plastic surfaces. A large part of the relevant studies has been carried out in vitro; these may or may not be relevant to events occurring in the intact host, as neither the functional anatomy of lymphoid tissue nor the remarkable mobility of some lymphocytes is taken into account." @default.
- W73470962 created "2016-06-24" @default.
- W73470962 creator A5011675080 @default.
- W73470962 creator A5077807895 @default.
- W73470962 date "1976-01-01" @default.
- W73470962 modified "2023-10-18" @default.
- W73470962 title "Role of Macrophages in T Cell–B Cell Collaboration in Antibody Production" @default.
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