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- W73506490 abstract "This chapter discusses the historical background, properties, pathogenesis, epizootiology, diagnosis, control, and prevention of Theiler's mouse encephalomyelitis virus (TMEV). TMEVs have provided models for studies of epidemiology, pathogenesis, virus multiplication, and inhibition by naturally occurring or contrived inhibitory agents and for recent immunopathological studies. The virus epidemiology provided a landmark model for studies on the fecal-oral transmission cycle of the polioviruses. TMEVs are RNA viruses close in size and other physical and chemical characteristics to the polioviruses and enteroviruses. They are very distinct from the latter two in terms of serology and host range but are similar to some of them in epidemiology and pathophysiology. The viruses are separable into two groups based on biological behavior: (1) highly virulent isolates unable to cause persistent infection and (2) less virulent isolates that regularly produce persistent central nervous system (CNS) infection in mice. The first line in diagnosis is the recognition of a paralyzed mouse among colony animals, an event that even in non-barrier colonies occurs no more frequently than once in 10,000 animals. The presence of disease in infected colonies or breeding stocks is usually made by hemagglutination inhibition testing of serum specimens from individual mice or of serum pools of several mice." @default.
- W73506490 created "2016-06-24" @default.
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- W73506490 date "1982-01-01" @default.
- W73506490 modified "2023-09-24" @default.
- W73506490 title "Mouse Encephalomyelitis Virus" @default.
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- W73506490 doi "https://doi.org/10.1016/b978-0-12-262502-2.50024-9" @default.
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