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• W73526163 endingPage "75" @default.
• W73526163 startingPage "164" @default.
• W73526163 abstract "The finding that telomere shortening limits the replicative lifespan of primary human cells has fueled speculations that telomere shortening plays a role during aging and regeneration of tissues in vivo. Support for this hypothesis comes from studies showing telomere shortening in a variety of human tissues as a consequence of aging and chronic disease. Studies in telomerase-deficient mice have given first experimental support that telomere shortening limits the replicative potential of organs and tissues in vivo and have identified telomerase as a promising target to treat regenerative disorders induced by telomere shortening. A potential downside of such an approach could be the development of malignant tumors, which has been linked to reactivation of telomerase in human cancers. In telomerase-deficient mice, telomere shortening showed a dual role in tumorigenesis, enhancing the initiation of tumors by induction of chromosomal instability but inhibiting tumor progression by induction of DNA-damage responses. The success in using telomerase activation for the treatment of regenerative disorders could depend on which of the mechanisms of telomere shortening is dominantly effecting carcinogenesis." @default.
• W73526163 created "2016-06-24" @default.
• W73526163 creator A5024453302 @default.
• W73526163 creator A5044834289 @default.
• W73526163 creator A5082881561 @default.
• W73526163 creator A5089101809 @default.
• W73526163 date "2003-04-30" @default.
• W73526163 modified "2023-09-29" @default.
• W73526163 title "Telomeres and telomerase in aging, regeneration and cancer." @default.
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