Matches in SemOpenAlex for { <https://semopenalex.org/work/W7353251> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W7353251 endingPage "12203" @default.
- W7353251 startingPage "12199" @default.
- W7353251 abstract "The cell-free synthesis of hyaluronic acid has been demonstrated in extracts of cultured human fibroblasts. Preparations from fibroblasts of normal individuals as well as those from patients with Marfan syndrome incorporate glucuronic acid and N-acetylglucosamine from their UDP derivatives into hyaluronic acid. Extracts from Marfan fibroblasts demonstrate 3 to 10 times more total and specific hyaluronic acid synthetase activity than do preparations from normal fibroblasts. All synthetic activity was found in particulate fractions with the bulk of activity localized in material sedimenting as large membrane fragments. Marfan and normal preparations exhibited similar properties with respect to substrate, cofactor, pH requirements, and heat stability. Neither the Marfan nor normal enzyme systems could be stimulated by exogenous acceptors, nor did either preparation contain a soluble factor which stimulated or inhibited the enzymic activity of the other. The genetic defect in Marfan syndrome appears to result in increased activity of hyaluronic acid synthetase without demonstrable changes in properties of the particulate enzymes involved." @default.
- W7353251 created "2016-06-24" @default.
- W7353251 creator A5044234765 @default.
- W7353251 creator A5053477572 @default.
- W7353251 creator A5055672181 @default.
- W7353251 date "1979-12-01" @default.
- W7353251 modified "2023-10-18" @default.
- W7353251 title "Cell-free synthesis of hyaluronic acid in Marfan syndrome." @default.
- W7353251 cites W1491167803 @default.
- W7353251 cites W1500055823 @default.
- W7353251 cites W1516201991 @default.
- W7353251 cites W1775749144 @default.
- W7353251 cites W1972650187 @default.
- W7353251 cites W1998775261 @default.
- W7353251 cites W2002414698 @default.
- W7353251 cites W2007330535 @default.
- W7353251 cites W2019136523 @default.
- W7353251 cites W2030393024 @default.
- W7353251 cites W2068214254 @default.
- W7353251 cites W2069983015 @default.
- W7353251 cites W2078679487 @default.
- W7353251 cites W2079684678 @default.
- W7353251 cites W2080876006 @default.
- W7353251 cites W2153046889 @default.
- W7353251 cites W2163419065 @default.
- W7353251 cites W2409939113 @default.
- W7353251 cites W2910177068 @default.
- W7353251 doi "https://doi.org/10.1016/s0021-9258(19)86449-9" @default.
- W7353251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/500705" @default.
- W7353251 hasPublicationYear "1979" @default.
- W7353251 type Work @default.
- W7353251 sameAs 7353251 @default.
- W7353251 citedByCount "74" @default.
- W7353251 countsByYear W73532512015 @default.
- W7353251 crossrefType "journal-article" @default.
- W7353251 hasAuthorship W7353251A5044234765 @default.
- W7353251 hasAuthorship W7353251A5053477572 @default.
- W7353251 hasAuthorship W7353251A5055672181 @default.
- W7353251 hasBestOaLocation W73532511 @default.
- W7353251 hasConcept C105702510 @default.
- W7353251 hasConcept C126322002 @default.
- W7353251 hasConcept C185592680 @default.
- W7353251 hasConcept C2777529286 @default.
- W7353251 hasConcept C2780561598 @default.
- W7353251 hasConcept C55493867 @default.
- W7353251 hasConcept C71924100 @default.
- W7353251 hasConcept C86803240 @default.
- W7353251 hasConcept C95444343 @default.
- W7353251 hasConceptScore W7353251C105702510 @default.
- W7353251 hasConceptScore W7353251C126322002 @default.
- W7353251 hasConceptScore W7353251C185592680 @default.
- W7353251 hasConceptScore W7353251C2777529286 @default.
- W7353251 hasConceptScore W7353251C2780561598 @default.
- W7353251 hasConceptScore W7353251C55493867 @default.
- W7353251 hasConceptScore W7353251C71924100 @default.
- W7353251 hasConceptScore W7353251C86803240 @default.
- W7353251 hasConceptScore W7353251C95444343 @default.
- W7353251 hasIssue "23" @default.
- W7353251 hasLocation W73532511 @default.
- W7353251 hasOpenAccess W7353251 @default.
- W7353251 hasPrimaryLocation W73532511 @default.
- W7353251 hasRelatedWork W1964799763 @default.
- W7353251 hasRelatedWork W1973023675 @default.
- W7353251 hasRelatedWork W1996374559 @default.
- W7353251 hasRelatedWork W2386452954 @default.
- W7353251 hasRelatedWork W2736827820 @default.
- W7353251 hasRelatedWork W2748952813 @default.
- W7353251 hasRelatedWork W2899084033 @default.
- W7353251 hasRelatedWork W3043535321 @default.
- W7353251 hasRelatedWork W3087022621 @default.
- W7353251 hasRelatedWork W3119264023 @default.
- W7353251 hasVolume "254" @default.
- W7353251 isParatext "false" @default.
- W7353251 isRetracted "false" @default.
- W7353251 magId "7353251" @default.
- W7353251 workType "article" @default.