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- W7356885 abstract "Many diseases are hypersensitive to DNA damaging agents but only xeroderma pigmentosum is consistently DNA repair deficient. Groups A to G exhibit reduction in excision of pyrimidine dimers and other lesions, the variant an alteration in polymerization or ligation. Pulse chase experiments indicate that excision defective and variant cells suffer increased blocking of replication forks during semiconservative replication after irradiation; but later bypass of such blocks is completely normal in all cell types. Thus, the variant is not defective in post-replication repair, and even the definition of such a system comes under question." @default.
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- W7356885 date "1979-01-01" @default.
- W7356885 modified "2023-09-23" @default.
- W7356885 title "Repair deficient and hypersensitive diseases of man" @default.
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