Matches in SemOpenAlex for { <https://semopenalex.org/work/W73591590> ?p ?o ?g. }
- W73591590 abstract "Exposure to acute hypoxia causes vasoconstriction in both pulmonary arteries (PA) and pulmonary veins (PV). The mechanisms on the arterial side have been studied extensively. However, bare attention has been paid to the venous side.To investigate if acute hypoxia caused the increase of intracellular Ca(2+) concentration ([Ca(2+)]i), and Ca(2+) influx through store-operated calcium channels (SOCC) in pulmonary venous smooth muscle cells (PVSMCs).Fluorescent microscopy and fura-2 were used to measure effects of 4% O2 on [Ca(2+)]i and store-operated Ca(2+) entry (SOCE) in isolated rat distal PVSMCs.In PVSMCs perfused with Ca(2+)-free Krebs Ringer bicarbonate solution (KRBS) containing cyclopiazonic acid to deplete Ca(2+) stores in the sarcoplasmic reticulum (SR) and nifedipine to prevent Ca(2+) entry through L-type voltage-depended Ca(2+) channels (VDCC), hypoxia markedly enhanced both the increase in [Ca(2+)]i caused by restoration of extracellular [Ca(2+)] and the rate at which extracellular Mn(2+) quenched fura-2 fluorescence. Moreover, the increased [Ca(2+)]i in PVSMCs perfused with normal salt solution was completely blocked by SOCC antagonists SKF-96365 and NiCl2 at concentrations that SOCE >85% was inhibited but [Ca(2+)]i responses to 60 mM KCl were not altered. On the contrary, L-type VDCC antagonist nifedipine inhibited increase in [Ca(2+)]i to hypoxia by only 50% at concentrations that completely blocked responses to KCl. The increased [Ca(2+)]i caused by hypoxia was completely abolished by perfusion with Ca(2+)-free KRBS.These results suggest that acute hypoxia enhances SOCE via activating SOCCs, leading to increased [Ca(2+)]i in distal PVSMCs." @default.
- W73591590 created "2016-06-24" @default.
- W73591590 creator A5002123396 @default.
- W73591590 creator A5011404538 @default.
- W73591590 creator A5022512665 @default.
- W73591590 creator A5032764121 @default.
- W73591590 creator A5071081238 @default.
- W73591590 date "2013-10-01" @default.
- W73591590 modified "2023-10-01" @default.
- W73591590 title "Acute hypoxia activates store-operated Ca(2+) entry and increases intracellular Ca(2+) concentration in rat distal pulmonary venous smooth muscle cells." @default.
- W73591590 cites W1250641235 @default.
- W73591590 cites W145922606 @default.
- W73591590 cites W1589364751 @default.
- W73591590 cites W1795554797 @default.
- W73591590 cites W1822055970 @default.
- W73591590 cites W1889047426 @default.
- W73591590 cites W1926185647 @default.
- W73591590 cites W1965345723 @default.
- W73591590 cites W1987690324 @default.
- W73591590 cites W2001558241 @default.
- W73591590 cites W2001756984 @default.
- W73591590 cites W2020276494 @default.
- W73591590 cites W2022787032 @default.
- W73591590 cites W2023455773 @default.
- W73591590 cites W2046359701 @default.
- W73591590 cites W2053095154 @default.
- W73591590 cites W2059497096 @default.
- W73591590 cites W2064686740 @default.
- W73591590 cites W2075502845 @default.
- W73591590 cites W2085516423 @default.
- W73591590 cites W2100577158 @default.
- W73591590 cites W2106050724 @default.
- W73591590 cites W2107475087 @default.
- W73591590 cites W2113370663 @default.
- W73591590 cites W2119953180 @default.
- W73591590 cites W2121460090 @default.
- W73591590 cites W2124487669 @default.
- W73591590 cites W2124658641 @default.
- W73591590 cites W2128450740 @default.
- W73591590 cites W2137357027 @default.
- W73591590 cites W2138303189 @default.
- W73591590 cites W2140798426 @default.
- W73591590 cites W2148806848 @default.
- W73591590 cites W2149456557 @default.
- W73591590 cites W2150838171 @default.
- W73591590 cites W2155157539 @default.
- W73591590 cites W2161440135 @default.
- W73591590 cites W2164492968 @default.
- W73591590 cites W2165178433 @default.
- W73591590 cites W2166112873 @default.
- W73591590 cites W2168481378 @default.
- W73591590 cites W2189297449 @default.
- W73591590 cites W2200463709 @default.
- W73591590 cites W2238916873 @default.
- W73591590 cites W2254871804 @default.
- W73591590 cites W2266546728 @default.
- W73591590 cites W2311570504 @default.
- W73591590 cites W2335875126 @default.
- W73591590 cites W2395368251 @default.
- W73591590 cites W2406750524 @default.
- W73591590 cites W69924197 @default.
- W73591590 doi "https://doi.org/10.3978/j.issn.2072-1439.2013.08.68" @default.
- W73591590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3815740" @default.
- W73591590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24255773" @default.
- W73591590 hasPublicationYear "2013" @default.
- W73591590 type Work @default.
- W73591590 sameAs 73591590 @default.
- W73591590 citedByCount "6" @default.
- W73591590 countsByYear W735915902015 @default.
- W73591590 countsByYear W735915902017 @default.
- W73591590 countsByYear W735915902018 @default.
- W73591590 countsByYear W735915902022 @default.
- W73591590 crossrefType "journal-article" @default.
- W73591590 hasAuthorship W73591590A5002123396 @default.
- W73591590 hasAuthorship W73591590A5011404538 @default.
- W73591590 hasAuthorship W73591590A5022512665 @default.
- W73591590 hasAuthorship W73591590A5032764121 @default.
- W73591590 hasAuthorship W73591590A5071081238 @default.
- W73591590 hasConcept C12554922 @default.
- W73591590 hasConcept C126322002 @default.
- W73591590 hasConcept C134018914 @default.
- W73591590 hasConcept C178790620 @default.
- W73591590 hasConcept C185592680 @default.
- W73591590 hasConcept C2779066535 @default.
- W73591590 hasConcept C2779395532 @default.
- W73591590 hasConcept C2779961880 @default.
- W73591590 hasConcept C2779996123 @default.
- W73591590 hasConcept C2780940725 @default.
- W73591590 hasConcept C28406088 @default.
- W73591590 hasConcept C29323129 @default.
- W73591590 hasConcept C2992686903 @default.
- W73591590 hasConcept C519063684 @default.
- W73591590 hasConcept C540031477 @default.
- W73591590 hasConcept C55493867 @default.
- W73591590 hasConcept C71924100 @default.
- W73591590 hasConcept C7836513 @default.
- W73591590 hasConcept C79879829 @default.
- W73591590 hasConcept C86803240 @default.
- W73591590 hasConceptScore W73591590C12554922 @default.
- W73591590 hasConceptScore W73591590C126322002 @default.