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- W73604610 abstract "Abstract Dendritic cells (DC) are antigen presenting cells that have shown great potential as cancer vaccines when tested in conventional animal models. However, relating the induction of antitumor responses in mice to the efficacy in humans has been difficult. Here-in we describe the development of a xenotransplant model to detect the capacity for a DC-based vaccine to generate human anti-tumor T cell responses in vivo. Immunodeficient NOD/SCID/IL2r-gamma-null mice allow efficient engraftment and expansion of human peripheral blood leukocytes (huPBL). Over 3 weeks, the lymphoid organs of recipient mice are reconstituted with more than 70% of the spleen cells expressing human CD45. To evaluate anti-tumor responses, mice were engrafted with huPBL, implanted with human tumor cells, and then vaccinated with autologous DC expressing tumor antigens. Spleen cells showed a normal CD4:CD8 ratio, while CD8+ cells predominated in the tumor infiltrating lymphcytes (TIL). There was a significant decrease in naïve CD45RA T cells and an increase regulatory T at the tumor site. Immunized mice showed a decrease in tumor size, an increase in tumor-specific T cells, but not complete tumor resolution. This model may allow the character of TIL and the induction of human immune responses against cancer to be more realistically evaluated in vivo. This study is funded by NIH/NIDA R01-DA03018 and by the NIH/NCI UCLA SPORE in Prostate Cancer." @default.
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- W73604610 date "2009-04-01" @default.
- W73604610 modified "2023-09-26" @default.
- W73604610 title "Evaluation of dendritic cell based cancer vaccines with a huPBL-NOD/SCID/IL2r-gamma-null xenotransplant model (41.7)" @default.
- W73604610 doi "https://doi.org/10.4049/jimmunol.182.supp.41.7" @default.
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