Matches in SemOpenAlex for { <https://semopenalex.org/work/W73647409> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W73647409 endingPage "574" @default.
- W73647409 startingPage "572" @default.
- W73647409 abstract "DNA damage blocks the progress of the replication fork. In order to bypass this damage, cells have evolved special DNA polymerases, which are uniquely able to replicate past damaged DNA. DNA polymerase η (polη) is the enzyme that carries out this bypass function (translesion synthesis) for the major form of ultraviolet damage in DNA. A deficiency in this polymerase leads to a severe human condition, the variant form of xeroderma pigmentosum. The highly conserved polymerase catalytic domain is located in the N-terminal 430 amino acids, whereas the C-terminal third contains motifs involved in protein–protein interactions. In particular, three motifs in the C-terminal 100 amino acids are required for correct localization of the polymerase in nuclear replication factories and for interaction with the ubiquitinated form of proliferating cell nuclear antigen. This interaction facilitates the switching of the blocked template–primer into the active site of (polη) to allow translesion synthesis to take place." @default.
- W73647409 created "2016-06-24" @default.
- W73647409 creator A5048471316 @default.
- W73647409 date "2013-01-01" @default.
- W73647409 modified "2023-09-26" @default.
- W73647409 title "XPV Polymerase and the Bypass of Ultraviolet DNA Damage" @default.
- W73647409 cites W1581236180 @default.
- W73647409 cites W2001209925 @default.
- W73647409 cites W2065626377 @default.
- W73647409 cites W2099367992 @default.
- W73647409 cites W2143064529 @default.
- W73647409 doi "https://doi.org/10.1016/b978-0-12-378630-2.00271-1" @default.
- W73647409 hasPublicationYear "2013" @default.
- W73647409 type Work @default.
- W73647409 sameAs 73647409 @default.
- W73647409 citedByCount "1" @default.
- W73647409 countsByYear W736474092016 @default.
- W73647409 crossrefType "book-chapter" @default.
- W73647409 hasAuthorship W73647409A5048471316 @default.
- W73647409 hasConcept C104317684 @default.
- W73647409 hasConcept C116988904 @default.
- W73647409 hasConcept C143425029 @default.
- W73647409 hasConcept C153911025 @default.
- W73647409 hasConcept C156719811 @default.
- W73647409 hasConcept C164965036 @default.
- W73647409 hasConcept C178790620 @default.
- W73647409 hasConcept C185592680 @default.
- W73647409 hasConcept C2756471 @default.
- W73647409 hasConcept C2777563447 @default.
- W73647409 hasConcept C2778378917 @default.
- W73647409 hasConcept C2987116853 @default.
- W73647409 hasConcept C31254050 @default.
- W73647409 hasConcept C34688535 @default.
- W73647409 hasConcept C49105822 @default.
- W73647409 hasConcept C552990157 @default.
- W73647409 hasConcept C55493867 @default.
- W73647409 hasConcept C58167604 @default.
- W73647409 hasConcept C73573662 @default.
- W73647409 hasConcept C75473681 @default.
- W73647409 hasConcept C76535049 @default.
- W73647409 hasConcept C82381507 @default.
- W73647409 hasConcept C86803240 @default.
- W73647409 hasConcept C88354546 @default.
- W73647409 hasConceptScore W73647409C104317684 @default.
- W73647409 hasConceptScore W73647409C116988904 @default.
- W73647409 hasConceptScore W73647409C143425029 @default.
- W73647409 hasConceptScore W73647409C153911025 @default.
- W73647409 hasConceptScore W73647409C156719811 @default.
- W73647409 hasConceptScore W73647409C164965036 @default.
- W73647409 hasConceptScore W73647409C178790620 @default.
- W73647409 hasConceptScore W73647409C185592680 @default.
- W73647409 hasConceptScore W73647409C2756471 @default.
- W73647409 hasConceptScore W73647409C2777563447 @default.
- W73647409 hasConceptScore W73647409C2778378917 @default.
- W73647409 hasConceptScore W73647409C2987116853 @default.
- W73647409 hasConceptScore W73647409C31254050 @default.
- W73647409 hasConceptScore W73647409C34688535 @default.
- W73647409 hasConceptScore W73647409C49105822 @default.
- W73647409 hasConceptScore W73647409C552990157 @default.
- W73647409 hasConceptScore W73647409C55493867 @default.
- W73647409 hasConceptScore W73647409C58167604 @default.
- W73647409 hasConceptScore W73647409C73573662 @default.
- W73647409 hasConceptScore W73647409C75473681 @default.
- W73647409 hasConceptScore W73647409C76535049 @default.
- W73647409 hasConceptScore W73647409C82381507 @default.
- W73647409 hasConceptScore W73647409C86803240 @default.
- W73647409 hasConceptScore W73647409C88354546 @default.
- W73647409 hasLocation W736474091 @default.
- W73647409 hasOpenAccess W73647409 @default.
- W73647409 hasPrimaryLocation W736474091 @default.
- W73647409 hasRelatedWork W1975201414 @default.
- W73647409 hasRelatedWork W2003506331 @default.
- W73647409 hasRelatedWork W2032289751 @default.
- W73647409 hasRelatedWork W2064129934 @default.
- W73647409 hasRelatedWork W2079497347 @default.
- W73647409 hasRelatedWork W2089751796 @default.
- W73647409 hasRelatedWork W2102188174 @default.
- W73647409 hasRelatedWork W2139971497 @default.
- W73647409 hasRelatedWork W2237831863 @default.
- W73647409 hasRelatedWork W73647409 @default.
- W73647409 isParatext "false" @default.
- W73647409 isRetracted "false" @default.
- W73647409 magId "73647409" @default.
- W73647409 workType "book-chapter" @default.