Matches in SemOpenAlex for { <https://semopenalex.org/work/W7366388> ?p ?o ?g. }
- W7366388 endingPage "8" @default.
- W7366388 startingPage "221" @default.
- W7366388 abstract "A number of tumor suppressor and tumor-related genes exhibit promoter hypermethylation with resulting gene silencing in human cancers. In addition, several gene promoters have also been shown to become hypermethylated in non-neoplastic cells during aging. To assess the physiological consequence and clinical significance of gene promoter methylation in gastric epithelia, our laboratory has studied the methylation status of tumor suppressor and tumor-related genes, including APC, DAP-kinase, DCC, E-cadherin, GSTP1, hMLH1, p16, PTEN, RASSF1A, RUNX3 and TSLC1, in neoplastic and non-neoplastic gastric epithelia. The tumor suppressor and tumor-related genes, except APC, were generally unmethylated in non-neoplastic gastric epithelia obtained from younger individuals. The frequencies of methylation increased with age to varying degrees in various genes, although GSTP1 and PTEN methylation was completely absent in both neoplastic and non-neoplastic gastric epithelia. The methylation frequencies in each gene were found to be comparable in neoplastic and non-neoplastic gastric epithelia, except the methylation of RUNX3 and TSLC1, which was mostly cancer-specific (P<0.01). When methylation frequencies were compared between non-neoplastic gastric epithelia from cancer-bearing and non-cancer-bearing stomachs, hMLH1 and p16 methylation was more frequent in those from cancer-bearing stomachs (P<0.01). Promoter methylation in tumor suppressor and tumor-related genes initially occurs in non-neoplastic gastric epithelia, increases with age, and ultimately silences gene function to constitute a field-defect that may predispose tissues to gastric cancer evolution. In clinical applications RUNX3 and TSLC1 methylation may be utilized as molecular diagnostic markers, and hMLH1 and p16 methylation as predictors of malignancy in the stomach." @default.
- W7366388 created "2016-06-24" @default.
- W7366388 creator A5035489073 @default.
- W7366388 date "2004-01-01" @default.
- W7366388 modified "2023-10-17" @default.
- W7366388 title "Promoter methylation status of tumor suppressor and tumor-related genes in neoplastic and non-neoplastic gastric epithelia." @default.
- W7366388 cites W1504197144 @default.
- W7366388 cites W1533251376 @default.
- W7366388 cites W1553454256 @default.
- W7366388 cites W1592729189 @default.
- W7366388 cites W1606687529 @default.
- W7366388 cites W1658127082 @default.
- W7366388 cites W1883475599 @default.
- W7366388 cites W1905924310 @default.
- W7366388 cites W1927497932 @default.
- W7366388 cites W1967137553 @default.
- W7366388 cites W1968391853 @default.
- W7366388 cites W1975993620 @default.
- W7366388 cites W1979125899 @default.
- W7366388 cites W1989454681 @default.
- W7366388 cites W1991702726 @default.
- W7366388 cites W1994465394 @default.
- W7366388 cites W1996495402 @default.
- W7366388 cites W1996831788 @default.
- W7366388 cites W2009335081 @default.
- W7366388 cites W2010269182 @default.
- W7366388 cites W2017620921 @default.
- W7366388 cites W2019109489 @default.
- W7366388 cites W2020393884 @default.
- W7366388 cites W2021527895 @default.
- W7366388 cites W2024405956 @default.
- W7366388 cites W2026262319 @default.
- W7366388 cites W2030194405 @default.
- W7366388 cites W2044224794 @default.
- W7366388 cites W2054000192 @default.
- W7366388 cites W2065128520 @default.
- W7366388 cites W2066164518 @default.
- W7366388 cites W2066848701 @default.
- W7366388 cites W2079385860 @default.
- W7366388 cites W2079985291 @default.
- W7366388 cites W2085853127 @default.
- W7366388 cites W2086112120 @default.
- W7366388 cites W2109684867 @default.
- W7366388 cites W2110042773 @default.
- W7366388 cites W2120436117 @default.
- W7366388 cites W2124947873 @default.
- W7366388 cites W2128146359 @default.
- W7366388 cites W2130198345 @default.
- W7366388 cites W2135025419 @default.
- W7366388 cites W2140317067 @default.
- W7366388 cites W2143375633 @default.
- W7366388 cites W2143510202 @default.
- W7366388 cites W2148883613 @default.
- W7366388 cites W2161810908 @default.
- W7366388 cites W2162845841 @default.
- W7366388 cites W2167284467 @default.
- W7366388 cites W2171080110 @default.
- W7366388 cites W2181932845 @default.
- W7366388 cites W2318855924 @default.
- W7366388 cites W2343052553 @default.
- W7366388 cites W2407583286 @default.
- W7366388 cites W81282519 @default.
- W7366388 doi "https://doi.org/10.14670/hh-19.221" @default.
- W7366388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14702190" @default.
- W7366388 hasPublicationYear "2004" @default.
- W7366388 type Work @default.
- W7366388 sameAs 7366388 @default.
- W7366388 citedByCount "24" @default.
- W7366388 countsByYear W73663882012 @default.
- W7366388 countsByYear W73663882013 @default.
- W7366388 countsByYear W73663882014 @default.
- W7366388 countsByYear W73663882015 @default.
- W7366388 countsByYear W73663882016 @default.
- W7366388 countsByYear W73663882017 @default.
- W7366388 countsByYear W73663882018 @default.
- W7366388 countsByYear W73663882019 @default.
- W7366388 countsByYear W73663882020 @default.
- W7366388 crossrefType "journal-article" @default.
- W7366388 hasAuthorship W7366388A5035489073 @default.
- W7366388 hasConcept C104317684 @default.
- W7366388 hasConcept C119056186 @default.
- W7366388 hasConcept C121608353 @default.
- W7366388 hasConcept C150194340 @default.
- W7366388 hasConcept C190727270 @default.
- W7366388 hasConcept C2777609662 @default.
- W7366388 hasConcept C2778264664 @default.
- W7366388 hasConcept C2993273003 @default.
- W7366388 hasConcept C33288867 @default.
- W7366388 hasConcept C502942594 @default.
- W7366388 hasConcept C54355233 @default.
- W7366388 hasConcept C555283112 @default.
- W7366388 hasConcept C62478195 @default.
- W7366388 hasConcept C86554907 @default.
- W7366388 hasConcept C86803240 @default.
- W7366388 hasConceptScore W7366388C104317684 @default.
- W7366388 hasConceptScore W7366388C119056186 @default.
- W7366388 hasConceptScore W7366388C121608353 @default.
- W7366388 hasConceptScore W7366388C150194340 @default.