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- W73672055 abstract "The first medical response to the presence of a brain tumor is often its resection, both to alleviate mass effect, and to obtain tissue for diagnosis, itself necessary for guiding adjunctive therapy. Malignant brain tumors typically recur at the tumor resection margin. Most current chemotherapy and radiotherapy strategies target local recurrence with limited success. Here we review a new strategy for delivering chemotherapeutics for brain tumor recurrence. It uses intra‐operative high‐intensity focused ultrasound (HIFU) to transiently open the blood‐brain barrier (BBB) over a significantly large volume of brain at and near the resection margin to enhance the subsequent delivery of systemically delivered chemotherapeutic agents into the region of tumor recurrence." @default.
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- W73672055 date "2006-01-01" @default.
- W73672055 modified "2023-09-27" @default.
- W73672055 title "Towards the use of HIFU, in Conjunction with Surgery, in the Treatment of Malignant Brain Tumors" @default.
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- W73672055 doi "https://doi.org/10.1063/1.2205469" @default.
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