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• W73677232 abstract "Chromosome instability (CIN), a continuous change in the structure or number of chromosomes, is proposed to be a key mechanism driving the genomic changes associated with tumorigenesis. One major cause of CIN in cells is chromosome segregational defects occurring during mitosis. Two such examples are anaphase bridges and multipolar spindles, which are common in most cancer cells and many tumor tissues.Anaphase bridges are chromatin bridges in between separating chromosome masses during anaphase, which may result in gene amplification or loss when breaking. We have found that cigarette smoke condensate (CSC) induced anaphase bridges in cultured primary human cells, which in a short time led to genomic imbalances. The frequency of the induced bridges within the entire population decreased with time, independent of the p53-mediated apoptotic pathway. We also showed that CSC induced DNA double-stranded breaks (DSBs) in cultured cells as well as purified DNA. The reactive oxygen species (ROS) scavenger, 2' deoxyguanosine 5'-monophosphate (dGMP) prevented CSC-induced DSBs, anaphase bridge formation and genomic imbalances. Therefore, we propose that CSC induces bridges and genomic imbalances via DNA DSBs. Further analysis in live oral cancer cells shows that cells with anaphase bridges mostly survive and these bridges frequently result in micronuclei formation, indicating that anaphase bridges actively contribute to CIN. Multipolar spindles (MPS) are aberrant mitotic structures when cells divide with greater than two spindle poles, which may result in uneven chromosome segregation. Multipolarity is strongly linked to centrosomal amplification, the mechanism of which remains controversial. We have examined the origin and fate of cells with MPS in real time. In both human embryonic kidney and oral cancer cells, the vast majority of multipolar cells originated from multinucleated cells. The frequency of cytokinesis failure was similar to the frequency of MPS, and each observed bipolar division that ended in a cytokinesis failure led to MPS formation in the subsequent mitosis. While grossly abnormal, these cells are still capable of dividing, often giving rise to a mixed progeny of multinucleated and mononucleated cells. These observations support the model that failure of cytokinesis may be the most common mechanism by which cells form MPS." @default.
• W73677232 created "2016-06-24" @default.
• W73677232 creator A5084736794 @default.
• W73677232 date "2005-02-04" @default.
• W73677232 modified "2023-09-23" @default.
• W73677232 title "Chromosome segregational defects: their origin, fate and contribution to genomic instability" @default.
• W73677232 cites W1482789507 @default.
• W73677232 cites W1483245334 @default.
• W73677232 cites W1483473129 @default.
• W73677232 cites W1488637588 @default.
• W73677232 cites W1498934519 @default.
• W73677232 cites W1502721583 @default.
• W73677232 cites W1509538618 @default.
• W73677232 cites W1522090640 @default.
• W73677232 cites W1544851750 @default.
• W73677232 cites W1580458764 @default.
• W73677232 cites W1583265575 @default.
• W73677232 cites W1583329274 @default.
• W73677232 cites W1593569677 @default.
• W73677232 cites W1602311424 @default.
• W73677232 cites W1622642497 @default.
• W73677232 cites W1635186783 @default.
• W73677232 cites W1676646253 @default.
• W73677232 cites W1712191184 @default.
• W73677232 cites W1846282020 @default.
• W73677232 cites W1852455217 @default.
• W73677232 cites W1935459338 @default.
• W73677232 cites W1943150066 @default.
• W73677232 cites W1964764218 @default.
• W73677232 cites W1967149801 @default.
• W73677232 cites W1967304777 @default.
• W73677232 cites W1968067337 @default.
• W73677232 cites W1968407767 @default.
• W73677232 cites W1969649126 @default.
• W73677232 cites W1971909077 @default.
• W73677232 cites W1971936152 @default.
• W73677232 cites W1972313386 @default.
• W73677232 cites W1972678218 @default.
• W73677232 cites W1975778708 @default.
• W73677232 cites W1978143866 @default.
• W73677232 cites W1978529327 @default.
• W73677232 cites W1979245530 @default.
• W73677232 cites W1979334696 @default.
• W73677232 cites W1980037769 @default.
• W73677232 cites W1980057048 @default.
• W73677232 cites W1983673827 @default.
• W73677232 cites W1985775217 @default.
• W73677232 cites W1986320226 @default.
• W73677232 cites W1986937402 @default.
• W73677232 cites W1988573682 @default.
• W73677232 cites W1988678729 @default.
• W73677232 cites W1989989615 @default.
• W73677232 cites W1991033145 @default.
• W73677232 cites W1992404055 @default.
• W73677232 cites W1992692440 @default.
• W73677232 cites W1993514197 @default.
• W73677232 cites W1994419156 @default.
• W73677232 cites W1994821070 @default.
• W73677232 cites W1995640224 @default.
• W73677232 cites W1995819860 @default.
• W73677232 cites W1998678044 @default.
• W73677232 cites W1998843589 @default.
• W73677232 cites W1999077006 @default.
• W73677232 cites W1999988680 @default.
• W73677232 cites W2000181213 @default.
• W73677232 cites W2001947684 @default.
• W73677232 cites W2004344140 @default.
• W73677232 cites W2005472812 @default.
• W73677232 cites W2007322428 @default.
• W73677232 cites W2010836341 @default.
• W73677232 cites W2010882280 @default.
• W73677232 cites W2011845715 @default.
• W73677232 cites W2013308696 @default.
• W73677232 cites W2014199526 @default.
• W73677232 cites W2014238550 @default.
• W73677232 cites W2016057553 @default.
• W73677232 cites W2016455125 @default.
• W73677232 cites W2016462887 @default.
• W73677232 cites W2016537596 @default.
• W73677232 cites W2018067226 @default.
• W73677232 cites W2019219567 @default.
• W73677232 cites W2020305530 @default.
• W73677232 cites W2021905009 @default.
• W73677232 cites W2022046751 @default.
• W73677232 cites W2022811243 @default.
• W73677232 cites W2025829112 @default.
• W73677232 cites W2025845692 @default.
• W73677232 cites W2026856506 @default.
• W73677232 cites W2027104770 @default.
• W73677232 cites W2027884659 @default.
• W73677232 cites W2028937947 @default.
• W73677232 cites W2030677909 @default.
• W73677232 cites W2031805729 @default.
• W73677232 cites W2032063427 @default.
• W73677232 cites W2032338576 @default.
• W73677232 cites W2032407757 @default.
• W73677232 cites W2034649293 @default.
• W73677232 cites W2035302026 @default.
• W73677232 cites W2037257739 @default.
• W73677232 cites W2037480531 @default.

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