FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W7380066> ?p ?o ?g. }

• W7380066 endingPage "7" @default.
• W7380066 startingPage "10" @default.
• W7380066 abstract "Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2). We have investigated the effect of gangliosides on the interaction of IL-2 with its cell surface receptors (IL-2R). Gangliosides inhibited IL-2-stimulated proliferation in synchronized populations of the IL-2-dependent cell lines CTLL-2 and HT-2. The immunosuppressive effect was most effective when gangliosides were added during the first 4 hr after IL-2-stimulation, indicating that they acted early in the IL-2 signalling pathway. Inhibition could be completely overcome by exogenous IL-2, suggesting that gangliosides inhibited growth solely by competing with IL-2R for available IL-2. In support of this proposal, gangliosides induced a concomitant dose-dependent decrease in binding of [125I]IL-2 to high-, medium- and low-affinity IL-2R. Ganglioside-treated cells recovered their high-affinity [125I]IL-2 binding after washing. The glycolipids also prevented chemical cross-linking of [125I]IL-2 to the p55/p75 complex, as well as to both IL-2R alpha (p55) and IL-2R beta (p75) independently. A thin-layer chromatography overlay technique was used to demonstrate that IL-2 binds directly to gangliosides, but not to simple neutral glycolipids or acidic lipids. Taken together, these findings indicate that gangliosides directly block the interaction of IL-2 with IL-2R, and may explain, in part, the immunosuppressive activities of gangliosides in vivo." @default.
• W7380066 created "2016-06-24" @default.
• W7380066 creator A5017042025 @default.
• W7380066 creator A5076632902 @default.
• W7380066 date "1993-05-01" @default.
• W7380066 modified "2023-10-18" @default.
• W7380066 title "Gangliosides inhibit T-lymphocyte proliferation by preventing the interaction of interleukin-2 with its cell surface receptors." @default.
• W7380066 cites W1506177294 @default.
• W7380066 cites W1521708233 @default.
• W7380066 cites W1524473114 @default.
• W7380066 cites W1971536925 @default.
• W7380066 cites W1974269271 @default.
• W7380066 cites W1976644790 @default.
• W7380066 cites W1978187207 @default.
• W7380066 cites W1993051112 @default.
• W7380066 cites W2007324489 @default.
• W7380066 cites W2018289835 @default.
• W7380066 cites W2023349831 @default.
• W7380066 cites W2027568763 @default.
• W7380066 cites W2031328794 @default.
• W7380066 cites W2040888475 @default.
• W7380066 cites W2051035159 @default.
• W7380066 cites W2064738820 @default.
• W7380066 cites W2068270731 @default.
• W7380066 cites W2070086352 @default.
• W7380066 cites W2074443036 @default.
• W7380066 cites W2088042664 @default.
• W7380066 cites W2090462947 @default.
• W7380066 cites W2090685643 @default.
• W7380066 cites W2090902670 @default.
• W7380066 cites W2100837269 @default.
• W7380066 cites W2112690101 @default.
• W7380066 cites W2119772880 @default.
• W7380066 cites W2129924739 @default.
• W7380066 cites W2141410410 @default.
• W7380066 cites W2164416194 @default.
• W7380066 cites W639870341 @default.
• W7380066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1422050" @default.
• W7380066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8509130" @default.
• W7380066 hasPublicationYear "1993" @default.
• W7380066 type Work @default.
• W7380066 sameAs 7380066 @default.
• W7380066 citedByCount "13" @default.
• W7380066 countsByYear W73800662015 @default.
• W7380066 countsByYear W73800662016 @default.
• W7380066 countsByYear W73800662017 @default.
• W7380066 countsByYear W73800662023 @default.
• W7380066 crossrefType "journal-article" @default.
• W7380066 hasAuthorship W7380066A5017042025 @default.
• W7380066 hasAuthorship W7380066A5076632902 @default.
• W7380066 hasConcept C1491633281 @default.
• W7380066 hasConcept C150903083 @default.
• W7380066 hasConcept C170493617 @default.
• W7380066 hasConcept C197462201 @default.
• W7380066 hasConcept C203014093 @default.
• W7380066 hasConcept C207001950 @default.
• W7380066 hasConcept C22222904 @default.
• W7380066 hasConcept C2776090121 @default.
• W7380066 hasConcept C2777331542 @default.
• W7380066 hasConcept C2777371288 @default.
• W7380066 hasConcept C2777761686 @default.
• W7380066 hasConcept C2778690821 @default.
• W7380066 hasConcept C55493867 @default.
• W7380066 hasConcept C62112901 @default.
• W7380066 hasConcept C86803240 @default.
• W7380066 hasConcept C8891405 @default.
• W7380066 hasConcept C95444343 @default.
• W7380066 hasConceptScore W7380066C1491633281 @default.
• W7380066 hasConceptScore W7380066C150903083 @default.
• W7380066 hasConceptScore W7380066C170493617 @default.
• W7380066 hasConceptScore W7380066C197462201 @default.
• W7380066 hasConceptScore W7380066C203014093 @default.
• W7380066 hasConceptScore W7380066C207001950 @default.
• W7380066 hasConceptScore W7380066C22222904 @default.
• W7380066 hasConceptScore W7380066C2776090121 @default.
• W7380066 hasConceptScore W7380066C2777331542 @default.
• W7380066 hasConceptScore W7380066C2777371288 @default.
• W7380066 hasConceptScore W7380066C2777761686 @default.
• W7380066 hasConceptScore W7380066C2778690821 @default.
• W7380066 hasConceptScore W7380066C55493867 @default.
• W7380066 hasConceptScore W7380066C62112901 @default.
• W7380066 hasConceptScore W7380066C86803240 @default.
• W7380066 hasConceptScore W7380066C8891405 @default.
• W7380066 hasConceptScore W7380066C95444343 @default.
• W7380066 hasIssue "1" @default.
• W7380066 hasLocation W73800661 @default.
• W7380066 hasOpenAccess W7380066 @default.
• W7380066 hasPrimaryLocation W73800661 @default.
• W7380066 hasRelatedWork W1928791235 @default.
• W7380066 hasRelatedWork W1976229112 @default.
• W7380066 hasRelatedWork W1999754601 @default.
• W7380066 hasRelatedWork W2011433123 @default.
• W7380066 hasRelatedWork W2045347928 @default.
• W7380066 hasRelatedWork W2087354339 @default.
• W7380066 hasRelatedWork W2156333347 @default.
• W7380066 hasRelatedWork W2414552866 @default.
• W7380066 hasRelatedWork W252418511 @default.
• W7380066 hasRelatedWork W3191162253 @default.

• next