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- W73867401 abstract "Abstract Oxidized phospholipids (OxPL) derived from oxidized lipoproteins or from membranes of apoptotic cells accumulate in damaged tissue. We hypothesized that OxPL generated during apoptosis may protect from inflammation through inducing a tolerogenic response. Our data shows that i.v. injection of C57BL/6 (B6) mice with OxPAPC (oxidation product of the membrane phospholipid 1-palmitoyl-2-arachidonoyl-sn-3-glycero-phosphoryl-choline) results in a reduced proportion of the CD11b-Hi CD11c+ dendritic cells (DC) in the spleen with much lower expression of MHC II and co-stimulatory molecules CD80 and CD86 as compared to saline injected controls. Furthermore, the number of CD4+Foxp3+ regulatory T cells (Tregs) was significantly higher in the spleens of mice treated with OxPAPC. Mechanistically, both the splenic CD11c+ DC purified from OxPAPC-treated mice and the OxPAPC-treated bone marrow-derived DC induced a more potent in vitro differentiation of naïve T cells to inducible Tregs as compared to the untreated controls. In a multiple low dose streptozotocin (MLD-STZ)-induced model of T1D, the B6 mice pre-treated with OxPAPC had a higher proportion of Tregs and were protected against MLD-STZ induced hyperglycemia as compared to saline injected controls. The data suggests that OxPAPC has therapeutic potential for treatment of T1D and other autoimmune diseases by inducing a DC-mediated increase of Treg differentiation." @default.
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- W73867401 date "2010-04-01" @default.
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- W73867401 title "Oxidized phospholopids induce a tolerogenic response that is protective in a Streptozotocin-induced model of type 1 diabetes (T1D) (87.19)" @default.
- W73867401 doi "https://doi.org/10.4049/jimmunol.184.supp.87.19" @default.
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