Matches in SemOpenAlex for { <https://semopenalex.org/work/W73889342> ?p ?o ?g. }
Showing items 1 to 47 of
47
with 100 items per page.
- W73889342 abstract "Aim. To pursue pharmacoeconomic analysis of two drug combinations of ACE inhibitor (enalapril) and diuretic. Material and methods. Patients with arterial hypertension degree 2 and diabetes mellitus type 2 without ischemic heart disease (n=56) were included into the study. Blood pressure (BP) dynamics and cost/effectiveness ratio were evaluated. Results. In group A (fixed combination of original enalapril/hydrochlorothiazide) 61% of patients achieved target BP level with initial dose, and the rest 39% of patients with double dose. In group B (non-fixed combination of generic enalapril/indapamide) 60% of patients achieved the target BP with initial dose of drugs, 33% with double dose of ACE inhibitor, and 7% with additional amlodipine administration. In patients of group A systolic BP (SBP) reduction was 45.82±1.23 mm Hg by the 12th week vs. 40.0±0.81 mm Hg in patients of group B; diastolic BP (DBP) reduction was 22.47±1.05 mm Hg and 18.76±0.70 mm Hg, respectively, by the 12th week of treatment. In the first month of treatment costs of target BP achievement was 298.62 rubles per patient in group A, and 299.50 rubles in group B; by the 1 2th week of treatment 629.45 and 631.22 rubles, respectively. Costs of SBP and DBP reduction by 1 mm Hg during 1 2 weeks of therapy were 13 and 27 rubles per patient, respectively, in group A, and 16 and 34 rubles per patient, respectively, in group B. Conclusion. The original fixed combination (enalapril+hydrochlorothiazide) proved to be more clinically effective and more cost effective in the treatment of hypertensive patients in comparison with the non-fixed combination of generic drugs (enalapril+indapamide)." @default.
- W73889342 created "2016-06-24" @default.
- W73889342 creator A5014843219 @default.
- W73889342 creator A5048331966 @default.
- W73889342 creator A5072543577 @default.
- W73889342 date "2014-01-01" @default.
- W73889342 modified "2023-09-24" @default.
- W73889342 title "Фармакоэкономический анализ использования комбинаций антигипертензивных препаратов" @default.
- W73889342 hasPublicationYear "2014" @default.
- W73889342 type Work @default.
- W73889342 sameAs 73889342 @default.
- W73889342 citedByCount "0" @default.
- W73889342 crossrefType "journal-article" @default.
- W73889342 hasAuthorship W73889342A5014843219 @default.
- W73889342 hasAuthorship W73889342A5048331966 @default.
- W73889342 hasAuthorship W73889342A5072543577 @default.
- W73889342 hasConcept C126322002 @default.
- W73889342 hasConcept C126894567 @default.
- W73889342 hasConcept C27016395 @default.
- W73889342 hasConcept C2775940317 @default.
- W73889342 hasConcept C2777748223 @default.
- W73889342 hasConcept C2779611605 @default.
- W73889342 hasConcept C2779918671 @default.
- W73889342 hasConcept C2780361556 @default.
- W73889342 hasConcept C2909726219 @default.
- W73889342 hasConcept C71924100 @default.
- W73889342 hasConcept C84393581 @default.
- W73889342 hasConceptScore W73889342C126322002 @default.
- W73889342 hasConceptScore W73889342C126894567 @default.
- W73889342 hasConceptScore W73889342C27016395 @default.
- W73889342 hasConceptScore W73889342C2775940317 @default.
- W73889342 hasConceptScore W73889342C2777748223 @default.
- W73889342 hasConceptScore W73889342C2779611605 @default.
- W73889342 hasConceptScore W73889342C2779918671 @default.
- W73889342 hasConceptScore W73889342C2780361556 @default.
- W73889342 hasConceptScore W73889342C2909726219 @default.
- W73889342 hasConceptScore W73889342C71924100 @default.
- W73889342 hasConceptScore W73889342C84393581 @default.
- W73889342 hasIssue "4" @default.
- W73889342 hasLocation W738893421 @default.
- W73889342 hasOpenAccess W73889342 @default.
- W73889342 hasPrimaryLocation W738893421 @default.
- W73889342 hasVolume "10" @default.
- W73889342 isParatext "false" @default.
- W73889342 isRetracted "false" @default.
- W73889342 magId "73889342" @default.
- W73889342 workType "article" @default.