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- W73896453 abstract "Dietary fiber and whole grains are implicated in prevention of cancer, but have been studied rarely with regard to prostate cancer aggressiveness. The associations among intake of whole grains, refined grains and total dietary fiber and aggressiveness of prostate cancer were examined among African Americans (AA, n=667) and Caucasian Americans (CA, n=820) in a population-based, case-only study (the North Carolina-Louisiana Prostate Cancer Project). Highly aggressive cases were defined as Gleason sum ≥8, or PSA>20ng/ml or Gleason sum=7 and stage cT3-cT4, and low/intermediate aggressive cases were defined as all others. Logistic regression was utilized to test for associations of prostate cancer aggressiveness with intake of refined grains, whole grains and dietary fiber, stratifying by race. There was a non-significant positive association between refined grains and risk of aggressive prostate cancer for AA (OR, 1.52; 95% CI, 0.82–2.82 for the 4th quartile compared to the 1st quartile of intake). A borderline significant inverse association between whole grain intake and prostate cancer aggressiveness was observed among CA (OR, 0.52; 95%CI, 0.27, 1.00). No other significant associations were observed. These results suggest that refined grain, whole grain and fiber intake are unlikely to be related substantially to prostate cancer aggressiveness. Grant Sponsor: Department of Defense “DAMD 17-03-2-0052”" @default.
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- W73896453 date "2010-04-01" @default.
- W73896453 modified "2023-10-03" @default.
- W73896453 title "Whole grain and dietary fiber intake and prostate cancer aggressiveness by race" @default.
- W73896453 doi "https://doi.org/10.1096/fasebj.24.1_supplement.729.2" @default.
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