Matches in SemOpenAlex for { <https://semopenalex.org/work/W73930215> ?p ?o ?g. }
- W73930215 abstract "Glycogen synthase kinase 3β (GSK3β) was discovered as a major factor in glucose homeostasis. GSK3β is a pivotal regulator of glycogen synthesis by altering the activity of glycogen synthase and perturbation in this process have been linked to at least some sub-entities of insulin resistance and diabetes mellitus. However, GSK3β has a central role in many biochemical and physiological processes apparently not related to insulin resistance or diabetes. The functionality of GSK3β is vast including more than 33 substrates and 72 protein-protein interactions, and is involved in such diverse diseases as cancer, schizophrenia, inflamation, cardiac diseases and many more. Considering this scale of the involvement of GSK3β, many related to developmental processes, suggests that either is GSK3β a high-level network-hub or is a peripheral kinase in several non-connected networks. Here, evidence is provided that GSK3β is an ultraconserved protein which would suggest that the enzyme qualify to be a kernel protein in the sense that life as we know it depends on conserved molecular entities to provide the essential functionality to an organism. The enzyme has evolved under strong purifying selection implicating that GSK3β is a functional hub." @default.
- W73930215 created "2016-06-24" @default.
- W73930215 creator A5006706174 @default.
- W73930215 creator A5045229961 @default.
- W73930215 creator A5051228367 @default.
- W73930215 creator A5075313176 @default.
- W73930215 creator A5082182601 @default.
- W73930215 creator A5082916255 @default.
- W73930215 date "2009-01-01" @default.
- W73930215 modified "2023-09-25" @default.
- W73930215 title "Is Glycogen Synthase Kinase-3β an Ultraconserved Kernel Enzyme?" @default.
- W73930215 cites W1489736060 @default.
- W73930215 cites W1518972222 @default.
- W73930215 cites W1568993576 @default.
- W73930215 cites W1654882305 @default.
- W73930215 cites W1799837960 @default.
- W73930215 cites W1837181255 @default.
- W73930215 cites W1895173308 @default.
- W73930215 cites W1964631519 @default.
- W73930215 cites W1965536495 @default.
- W73930215 cites W1967550038 @default.
- W73930215 cites W1970525278 @default.
- W73930215 cites W1972343960 @default.
- W73930215 cites W1973337583 @default.
- W73930215 cites W1975553093 @default.
- W73930215 cites W1981284961 @default.
- W73930215 cites W1981896603 @default.
- W73930215 cites W1983435458 @default.
- W73930215 cites W1984335236 @default.
- W73930215 cites W1984407262 @default.
- W73930215 cites W1988871238 @default.
- W73930215 cites W1992527405 @default.
- W73930215 cites W1995120027 @default.
- W73930215 cites W1997224330 @default.
- W73930215 cites W2004922458 @default.
- W73930215 cites W2006683252 @default.
- W73930215 cites W2009094422 @default.
- W73930215 cites W2010337187 @default.
- W73930215 cites W2011348124 @default.
- W73930215 cites W2013865207 @default.
- W73930215 cites W2014222652 @default.
- W73930215 cites W2014362480 @default.
- W73930215 cites W2014415555 @default.
- W73930215 cites W2014558162 @default.
- W73930215 cites W2016946796 @default.
- W73930215 cites W2019007505 @default.
- W73930215 cites W2021148680 @default.
- W73930215 cites W2026302885 @default.
- W73930215 cites W2026755839 @default.
- W73930215 cites W2037135039 @default.
- W73930215 cites W2038307473 @default.
- W73930215 cites W2040940215 @default.
- W73930215 cites W2041187152 @default.
- W73930215 cites W2044872382 @default.
- W73930215 cites W2046982257 @default.
- W73930215 cites W2047740187 @default.
- W73930215 cites W2049791640 @default.
- W73930215 cites W2050685224 @default.
- W73930215 cites W2053265248 @default.
- W73930215 cites W2053692735 @default.
- W73930215 cites W2053791137 @default.
- W73930215 cites W2053870616 @default.
- W73930215 cites W2056254608 @default.
- W73930215 cites W2057226438 @default.
- W73930215 cites W2060399360 @default.
- W73930215 cites W2061634271 @default.
- W73930215 cites W2062478949 @default.
- W73930215 cites W2062934426 @default.
- W73930215 cites W2063365464 @default.
- W73930215 cites W2065572957 @default.
- W73930215 cites W2066052992 @default.
- W73930215 cites W2066497759 @default.
- W73930215 cites W2074883812 @default.
- W73930215 cites W2078668373 @default.
- W73930215 cites W2082839004 @default.
- W73930215 cites W2083308747 @default.
- W73930215 cites W2085663173 @default.
- W73930215 cites W2086582316 @default.
- W73930215 cites W2092030376 @default.
- W73930215 cites W2092921985 @default.
- W73930215 cites W2093138775 @default.
- W73930215 cites W2094690507 @default.
- W73930215 cites W2096525273 @default.
- W73930215 cites W2098503611 @default.
- W73930215 cites W2100990361 @default.
- W73930215 cites W2101324476 @default.
- W73930215 cites W2102660198 @default.
- W73930215 cites W2102985891 @default.
- W73930215 cites W2104326963 @default.
- W73930215 cites W2105487208 @default.
- W73930215 cites W2108285073 @default.
- W73930215 cites W2110662963 @default.
- W73930215 cites W2110677712 @default.
- W73930215 cites W2112820874 @default.
- W73930215 cites W2114594254 @default.
- W73930215 cites W2115037145 @default.
- W73930215 cites W2115871573 @default.
- W73930215 cites W2119600157 @default.
- W73930215 cites W2127016797 @default.
- W73930215 cites W2129558195 @default.