Matches in SemOpenAlex for { <https://semopenalex.org/work/W7395310> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W7395310 endingPage "6" @default.
- W7395310 startingPage "571" @default.
- W7395310 abstract "By means of direct cell-cell contact, fixed, stimulated T lymphocytes trigger the production of interleukin-1 beta (IL-1 beta) and tumour necrosis factor by monocytes and prime polymorphonuclear leucocytes (PMN) for the respiratory burst induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP). In order to assess whether this activity is displayed by a particular subpopulation of T lymphocytes, 88 T-cell clones (TCC) were generated from healthy human peripheral blood. The clones were stimulated by Phaseolus vulgaris agglutinin (PHA) and phorbol 12-myristate acetate monocytic cell line THP-1. All fixed, stimulated TCC induced IL-1 beta production by THP-1 cells, although to varied degrees. The activity of TCC on THP-1 cells correlated with their activity on PMN (r2 = 0.84, P < 0.001), suggesting that this pro-inflammatory activity of TCC may similarly affect both types of infiltrating cells. The ability of TCC to modulate target cells did not correlate with either their phenotype (CD4 or CD8) or their cytokine production profile (interferon-gamma, IL-4 and IL-6), although it tended to correlate inversely with their capacity to produce IL-6 (P < 0.02). These observations suggest that a large proportion, if not all, of human peripheral blood T lymphocytes may potentially affect monocytes and PMN by direct cell-cell contact. This activity may be relevant to the maintenance of chronic inflammation." @default.
- W7395310 created "2016-06-24" @default.
- W7395310 creator A5024115434 @default.
- W7395310 creator A5035122264 @default.
- W7395310 creator A5058200133 @default.
- W7395310 creator A5073777288 @default.
- W7395310 date "1995-04-01" @default.
- W7395310 modified "2023-10-18" @default.
- W7395310 title "Contact-dependent stimulation of monocytic cells and neutrophils by stimulated human T-cell clones." @default.
- W7395310 cites W1438272007 @default.
- W7395310 cites W1534164957 @default.
- W7395310 cites W1543391587 @default.
- W7395310 cites W1545618546 @default.
- W7395310 cites W1559197028 @default.
- W7395310 cites W1581494057 @default.
- W7395310 cites W1897226866 @default.
- W7395310 cites W1968151442 @default.
- W7395310 cites W1968715761 @default.
- W7395310 cites W1981326080 @default.
- W7395310 cites W1987486103 @default.
- W7395310 cites W2007289040 @default.
- W7395310 cites W2049670055 @default.
- W7395310 cites W2088119350 @default.
- W7395310 cites W2107359414 @default.
- W7395310 cites W2135483134 @default.
- W7395310 cites W2153084851 @default.
- W7395310 cites W2460992717 @default.
- W7395310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1415156" @default.
- W7395310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7790031" @default.
- W7395310 hasPublicationYear "1995" @default.
- W7395310 type Work @default.
- W7395310 sameAs 7395310 @default.
- W7395310 citedByCount "22" @default.
- W7395310 countsByYear W73953102015 @default.
- W7395310 countsByYear W73953102017 @default.
- W7395310 crossrefType "journal-article" @default.
- W7395310 hasAuthorship W7395310A5024115434 @default.
- W7395310 hasAuthorship W7395310A5035122264 @default.
- W7395310 hasAuthorship W7395310A5058200133 @default.
- W7395310 hasAuthorship W7395310A5073777288 @default.
- W7395310 hasConcept C134018914 @default.
- W7395310 hasConcept C137061746 @default.
- W7395310 hasConcept C153911025 @default.
- W7395310 hasConcept C167672396 @default.
- W7395310 hasConcept C17991360 @default.
- W7395310 hasConcept C202751555 @default.
- W7395310 hasConcept C203014093 @default.
- W7395310 hasConcept C24998067 @default.
- W7395310 hasConcept C2776090121 @default.
- W7395310 hasConcept C2778690821 @default.
- W7395310 hasConcept C2781184567 @default.
- W7395310 hasConcept C54355233 @default.
- W7395310 hasConcept C55493867 @default.
- W7395310 hasConcept C81885089 @default.
- W7395310 hasConcept C86803240 @default.
- W7395310 hasConcept C8891405 @default.
- W7395310 hasConceptScore W7395310C134018914 @default.
- W7395310 hasConceptScore W7395310C137061746 @default.
- W7395310 hasConceptScore W7395310C153911025 @default.
- W7395310 hasConceptScore W7395310C167672396 @default.
- W7395310 hasConceptScore W7395310C17991360 @default.
- W7395310 hasConceptScore W7395310C202751555 @default.
- W7395310 hasConceptScore W7395310C203014093 @default.
- W7395310 hasConceptScore W7395310C24998067 @default.
- W7395310 hasConceptScore W7395310C2776090121 @default.
- W7395310 hasConceptScore W7395310C2778690821 @default.
- W7395310 hasConceptScore W7395310C2781184567 @default.
- W7395310 hasConceptScore W7395310C54355233 @default.
- W7395310 hasConceptScore W7395310C55493867 @default.
- W7395310 hasConceptScore W7395310C81885089 @default.
- W7395310 hasConceptScore W7395310C86803240 @default.
- W7395310 hasConceptScore W7395310C8891405 @default.
- W7395310 hasIssue "4" @default.
- W7395310 hasLocation W73953101 @default.
- W7395310 hasOpenAccess W7395310 @default.
- W7395310 hasPrimaryLocation W73953101 @default.
- W7395310 hasRelatedWork W1970781119 @default.
- W7395310 hasRelatedWork W2028288720 @default.
- W7395310 hasRelatedWork W2085322992 @default.
- W7395310 hasRelatedWork W2110026760 @default.
- W7395310 hasRelatedWork W2124059797 @default.
- W7395310 hasRelatedWork W2408320609 @default.
- W7395310 hasRelatedWork W2505753356 @default.
- W7395310 hasRelatedWork W2735617581 @default.
- W7395310 hasRelatedWork W3044579596 @default.
- W7395310 hasRelatedWork W345330829 @default.
- W7395310 hasVolume "84" @default.
- W7395310 isParatext "false" @default.
- W7395310 isRetracted "false" @default.
- W7395310 magId "7395310" @default.
- W7395310 workType "article" @default.