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• W73972280 endingPage "463" @default.
• W73972280 startingPage "453" @default.
• W73972280 abstract "Osteoporosis is characterized by a decrease in bone mass and a deterioration in skeletal microarchitecture leading to an increased fragility and susceptibility to fracture.87 One of the major determinants of skeletal weakness results from bone loss occurring after the menopause as a consequence of an increased osteoclastic resorption, only partially compensated by a moderate rise in the rate of bone formation by osteoblasts.65 Prevention of early postmenopausal bone loss has been successfully achieved by the use of drugs which reduce or inhibit bone resorption. Estrogen,21 calcitonins,88, 90 and bisphosphonates42, 68, 91 are considered safe and effective ways to maintain mineral density of trabecular and cortical bone at premenopausal levels by counteracting the exacerbated activity of osteoclasts induced by the sharp postmenopausal decrease in circulating endogenous estrogens. However, in many cultural backgrounds, primary prevention of osteoporosis initiated in the immediate postmenopause is not yet considered as a public health priority by specialists dealing with bone metabolic disorders, primary care physicians, and the general population.84, 89 Subsequently, care takers often face complicated situations with women consulting for the first time at later stages of the disease, namely, after the diagnosis of osteoporosis has already been made on the basis of random radiographs, densitometry measurements or, even worse, a fracture. Unfortunately, none of the currently available medications has unequivocally demonstrated the ability to prevent fully the occurrence of new vertebral or peripheral osteoporotic fractures once the disease is established. Although promising results have been reported with inhibitors of bone resorption,14, 44, 57, 73, 109 patients treated with these drugs usually achieve modest increases in bone mass which translate into partial reduction of incident fractures when compared with the rate in subjects receiving a placebo or treated with calcium alone. These rather disappointing results are jeopardized by either potential severe toxicity8, 11, 12, 60 or unbearable costs,82 discouraging widespread or prolonged use of the drugs. Although emerging bisphosphonate drugs86, 113 seem to be more effective and better tolerated, there is little chance their use will restore bone mineral density to normal values and radically prevent the occurrence of new fracture events. Therefore, there is an urgent need for the development of medications with a better risk-to-benefit (efficacy versus tolerance) ratio in comparison with available medications." @default.
• W73972280 created "2016-06-24" @default.
• W73972280 creator A5002350588 @default.
• W73972280 creator A5025729444 @default.
• W73972280 creator A5028502093 @default.
• W73972280 date "1998-06-01" @default.
• W73972280 modified "2023-10-14" @default.
• W73972280 title "THERAPY FOR OSTEOPOROSIS" @default.
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