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• W73984174 abstract "Systemic treatment of malignant disease now has a modern history of over 50 yr. Over that time, the successes of chemotherapy in curing cancer have been in leukemia, lymphoma, and selected solid tumors such as testis cancer. The administration of very high doses of chemotherapy requiring hematopoietic stem cell support has had more than a 10-yr history (1–5). Even with this heroic treatment, cure of solid tumors, such as breast cancer and small-cell lung cancer, remains elusive (6–8). High-dose chemotherapy regimens with hematopoietic stem cell support allowed the frequency of complete clinical response to be markedly increased; however, over the first 1–2 yr after therapy, tumors in most patients recur. These results, as well as the predictable times and patterns of recurrence of many solid tumors after standard courses of chemotherapy or standard regimens of radiation therapy, have led to the hypothesis that a few viable malignant cells with proliferative capacity remain after therapy and eventually repopulate the primary tumor and/or grow into metastatic lesions. These minimal residual tumor cells exist at levels below detectability by standard techniques. Dendritic cell (DC)-based cancers are currently being evaluated for the treatment of minimal residual disease (9)." @default.
• W73984174 created "2016-06-24" @default.
• W73984174 creator A5040137655 @default.
• W73984174 date "2004-01-01" @default.
• W73984174 modified "2023-09-23" @default.
• W73984174 title "Models for Biomarkers and Minimal Residual Tumor" @default.
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• W73984174 doi "https://doi.org/10.1007/978-1-59259-739-0_11" @default.
• W73984174 hasPublicationYear "2004" @default.
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