Matches in SemOpenAlex for { <https://semopenalex.org/work/W74113722> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W74113722 endingPage "152.15" @default.
- W74113722 startingPage "152.15" @default.
- W74113722 abstract "Abstract Nuclear erythroid 2 related factor 2 (Nrf2) is a transcription factor activated by cell stress, including oxidative and electrophilic stimuli, resulting in the upregulation of a battery of cytoprotective genes. Although best known for its role in detoxication, Nrf2 has also been shown to have a number of anti-inflammatory effects. The role of Nrf2 in T cells is largely unknown, however. Nrf2 can be activated experimentally by a number of different pharmacological agents, including tert-butylhydroquinone (tBHQ), which is also used commercially as a food preservative. The present studies found that the Nrf2 activator, tBHQ, suppresses production of IFNγ in activated CD4+ cells, while concurrently inducing production of IL-4, IL-5, and IL-13. These effects were also observed in CD4+ cells that were stimulated with anti-CD3/anti-CD28 in the presence tBHQ for 5 days and then restimulated without further addition of Nrf2 activators, suggesting that the effects are due to CD4+ cell differentiation. Furthermore, the current studies suggest that activation of Nrf2 diminishes T-bet binding activity, while concurrently enhancing GATA-3 binding activity. Collectively, the present studies suggest that activation of Nrf2 has a suppressive effect on Th1 differentiation, while promoting Th2 differentiation, which likely occurs through inhibition of T-bet activity and potentiation of GATA-3 activity." @default.
- W74113722 created "2016-06-24" @default.
- W74113722 creator A5015421326 @default.
- W74113722 creator A5055298886 @default.
- W74113722 creator A5076743166 @default.
- W74113722 creator A5081776292 @default.
- W74113722 date "2011-04-01" @default.
- W74113722 modified "2023-10-12" @default.
- W74113722 title "Activation of Nrf2 skews CD4+ cells toward Th2 differentiation (152.15)" @default.
- W74113722 doi "https://doi.org/10.4049/jimmunol.186.supp.152.15" @default.
- W74113722 hasPublicationYear "2011" @default.
- W74113722 type Work @default.
- W74113722 sameAs 74113722 @default.
- W74113722 citedByCount "0" @default.
- W74113722 crossrefType "journal-article" @default.
- W74113722 hasAuthorship W74113722A5015421326 @default.
- W74113722 hasAuthorship W74113722A5055298886 @default.
- W74113722 hasAuthorship W74113722A5076743166 @default.
- W74113722 hasAuthorship W74113722A5081776292 @default.
- W74113722 hasConcept C104317684 @default.
- W74113722 hasConcept C127561419 @default.
- W74113722 hasConcept C148125776 @default.
- W74113722 hasConcept C148738053 @default.
- W74113722 hasConcept C154317977 @default.
- W74113722 hasConcept C185592680 @default.
- W74113722 hasConcept C202751555 @default.
- W74113722 hasConcept C55493867 @default.
- W74113722 hasConcept C86339819 @default.
- W74113722 hasConcept C86803240 @default.
- W74113722 hasConcept C88045685 @default.
- W74113722 hasConcept C95444343 @default.
- W74113722 hasConceptScore W74113722C104317684 @default.
- W74113722 hasConceptScore W74113722C127561419 @default.
- W74113722 hasConceptScore W74113722C148125776 @default.
- W74113722 hasConceptScore W74113722C148738053 @default.
- W74113722 hasConceptScore W74113722C154317977 @default.
- W74113722 hasConceptScore W74113722C185592680 @default.
- W74113722 hasConceptScore W74113722C202751555 @default.
- W74113722 hasConceptScore W74113722C55493867 @default.
- W74113722 hasConceptScore W74113722C86339819 @default.
- W74113722 hasConceptScore W74113722C86803240 @default.
- W74113722 hasConceptScore W74113722C88045685 @default.
- W74113722 hasConceptScore W74113722C95444343 @default.
- W74113722 hasIssue "1_Supplement" @default.
- W74113722 hasLocation W741137221 @default.
- W74113722 hasOpenAccess W74113722 @default.
- W74113722 hasPrimaryLocation W741137221 @default.
- W74113722 hasRelatedWork W1969200465 @default.
- W74113722 hasRelatedWork W2131613539 @default.
- W74113722 hasRelatedWork W2160940770 @default.
- W74113722 hasRelatedWork W2520434374 @default.
- W74113722 hasRelatedWork W2783679151 @default.
- W74113722 hasRelatedWork W2973133007 @default.
- W74113722 hasRelatedWork W3115150918 @default.
- W74113722 hasRelatedWork W3163001661 @default.
- W74113722 hasRelatedWork W4210757985 @default.
- W74113722 hasRelatedWork W4225014292 @default.
- W74113722 hasVolume "186" @default.
- W74113722 isParatext "false" @default.
- W74113722 isRetracted "false" @default.
- W74113722 magId "74113722" @default.
- W74113722 workType "article" @default.