Matches in SemOpenAlex for { <https://semopenalex.org/work/W74137465> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W74137465 abstract "In our previous studies we found that quail embryos incubated under hypoxic conditions (16 % O2) die at embryonic day (ED) 9 with signs of heart failure. By ED 4 and 6 we found thinner ventricular wall and increased capillary density. We thus hypothesized that the cause of death would lie in severe coronary maldevelopment. We analyzed serial histological sections of normoxic and hypoxic hearts from ED 6, 7, 8, and 9. In ED 6 and 7 hypoxic hearts we found thinner wall in all compartments, especially the left ventricle. Simultaneously we found an increase in capillary density in interventricular septum. This site corresponds to an area of tissue hypoxia and ensuing increased angiogenesis. In sections from ED 9 hypoxic hearts we found irregularities in development of coronary tree (missing coronary ostia, absence of one coronary artery, and thinner arterial wall). By injection of ink through the left ventricle to the coronary arteries we found in normoxic specimens regular coronary branching pattern, while in the hypoxic ones there was only irregular plexus. In conclusion, hypoxia leads to increased capilarization and trabecularization to minimize diffusion distance. In the subsequent period there is a failure in organization of vascular plexus into normal vasculature, leading to heart failure and embryonic death. Supported by grant No. 0021620806 from the Ministry of Education of the Czech Republic." @default.
- W74137465 created "2016-06-24" @default.
- W74137465 creator A5060304573 @default.
- W74137465 creator A5061106072 @default.
- W74137465 creator A5089127172 @default.
- W74137465 date "2007-01-01" @default.
- W74137465 modified "2023-09-27" @default.
- W74137465 title "Abnormal coronary tree development in embryonic hypoxia leads to heart failure and embryonic lethality" @default.
- W74137465 doi "https://doi.org/10.1096/fasebj.21.6.a974-c" @default.
- W74137465 hasPublicationYear "2007" @default.
- W74137465 type Work @default.
- W74137465 sameAs 74137465 @default.
- W74137465 citedByCount "0" @default.
- W74137465 crossrefType "journal-article" @default.
- W74137465 hasAuthorship W74137465A5060304573 @default.
- W74137465 hasAuthorship W74137465A5061106072 @default.
- W74137465 hasAuthorship W74137465A5089127172 @default.
- W74137465 hasConcept C104317684 @default.
- W74137465 hasConcept C105702510 @default.
- W74137465 hasConcept C126322002 @default.
- W74137465 hasConcept C145103041 @default.
- W74137465 hasConcept C164705383 @default.
- W74137465 hasConcept C178790620 @default.
- W74137465 hasConcept C185592680 @default.
- W74137465 hasConcept C2776820930 @default.
- W74137465 hasConcept C2777837822 @default.
- W74137465 hasConcept C2778198053 @default.
- W74137465 hasConcept C2778742706 @default.
- W74137465 hasConcept C2778921608 @default.
- W74137465 hasConcept C2779740085 @default.
- W74137465 hasConcept C2780231137 @default.
- W74137465 hasConcept C540031477 @default.
- W74137465 hasConcept C55493867 @default.
- W74137465 hasConcept C71924100 @default.
- W74137465 hasConcept C7836513 @default.
- W74137465 hasConcept C86803240 @default.
- W74137465 hasConceptScore W74137465C104317684 @default.
- W74137465 hasConceptScore W74137465C105702510 @default.
- W74137465 hasConceptScore W74137465C126322002 @default.
- W74137465 hasConceptScore W74137465C145103041 @default.
- W74137465 hasConceptScore W74137465C164705383 @default.
- W74137465 hasConceptScore W74137465C178790620 @default.
- W74137465 hasConceptScore W74137465C185592680 @default.
- W74137465 hasConceptScore W74137465C2776820930 @default.
- W74137465 hasConceptScore W74137465C2777837822 @default.
- W74137465 hasConceptScore W74137465C2778198053 @default.
- W74137465 hasConceptScore W74137465C2778742706 @default.
- W74137465 hasConceptScore W74137465C2778921608 @default.
- W74137465 hasConceptScore W74137465C2779740085 @default.
- W74137465 hasConceptScore W74137465C2780231137 @default.
- W74137465 hasConceptScore W74137465C540031477 @default.
- W74137465 hasConceptScore W74137465C55493867 @default.
- W74137465 hasConceptScore W74137465C71924100 @default.
- W74137465 hasConceptScore W74137465C7836513 @default.
- W74137465 hasConceptScore W74137465C86803240 @default.
- W74137465 hasFunder F4320321005 @default.
- W74137465 hasIssue "6" @default.
- W74137465 hasLocation W741374651 @default.
- W74137465 hasOpenAccess W74137465 @default.
- W74137465 hasPrimaryLocation W741374651 @default.
- W74137465 hasRelatedWork W1968424292 @default.
- W74137465 hasRelatedWork W1982904431 @default.
- W74137465 hasRelatedWork W1988906123 @default.
- W74137465 hasRelatedWork W2024549923 @default.
- W74137465 hasRelatedWork W2158553116 @default.
- W74137465 hasRelatedWork W2184731283 @default.
- W74137465 hasRelatedWork W2916521439 @default.
- W74137465 hasRelatedWork W2953579136 @default.
- W74137465 hasRelatedWork W3008404335 @default.
- W74137465 hasRelatedWork W4313837430 @default.
- W74137465 hasVolume "21" @default.
- W74137465 isParatext "false" @default.
- W74137465 isRetracted "false" @default.
- W74137465 magId "74137465" @default.
- W74137465 workType "article" @default.