FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W74156619> ?p ?o ?g. }

• W74156619 abstract "Extracorporeal blood purification is a promising therapeutic modality for sepsis, a potentially fatal, dysfunctional immune disorder caused by infection. During sepsis, dysregulation of the innate immune system leads to excessive release of inflammatory mediators known as cytokines into the bloodstream. Removal of cytokines from the circulating blood may attenuate hyper-inflammatory signaling and promote immunologic homeostasis. We are developing an extracorporeal blood purification device to remove cytokines from the blood using biocompatible, porous, polymeric beads. Hemoadsorption therapy using our device has demonstrated improved survival in a murine sepsis model, and may serve as a novel adjuvant therapy to improve patient outcomes in the setting of severe sepsis and septic shock.We developed a mathematical model to characterize cytokine adsorption dynamics within the device, and used confocal laser scanning microscopy (CLSM) to quantify cytokine transport within single sorbent beads. Finite element modeling was utilized to estimate model parameters based on best fits to CLSM data, and the fitted model was used to simulate cytokine adsorption behavior under clinically relevant conditions. We investigated intraparticle cytokine transport under competitive and non-competitive adsorption conditions, and demonstrated that effects due to coadsorption of serum solutes are likely negligible under physiologic cytokine concentrations. CLSM results indicate that less than 20% of available sorbent surface area is utilized for cytokine adsorption. Tumor necrosis factor (TNF) is a pleiotropic, pro-inflammatory cytokine, and serves as a primary initiator of systemic inflammation during sepsis. Removal of TNF within the device is slow, putatively due to hindered diffusion of the large TNF molecule (51kD) within the sorbent pores. We induced deoligomerization of trimeric TNF into its monomeric subunits, and demonstrated significantly accelerated capture of monomerized TNF within the device, compared to native TNF. We investigated small molecules capable of facilitating TNF deoligomerization, and proposed techniques to immobilize such molecules on the sorbent surface. Functionalized sorbent beads capable of locally dissociating TNF at the bead surface may significantly accelerate capture of TNF from the circulating blood. This concept could be expanded to enhance capture of oligomeric biomolecules using size exclusion filtration materials for a variety of disease states." @default.
• W74156619 created "2016-06-24" @default.
• W74156619 creator A5036851796 @default.
• W74156619 date "2011-09-19" @default.
• W74156619 modified "2023-09-24" @default.
• W74156619 title "Characterizing cytokine transport in hemoadsorption beads used to treat sepsis" @default.
• W74156619 cites W102263367 @default.
• W74156619 cites W109001113 @default.
• W74156619 cites W1090352659 @default.
• W74156619 cites W1490166156 @default.
• W74156619 cites W1492950536 @default.
• W74156619 cites W1541486667 @default.
• W74156619 cites W1543580221 @default.
• W74156619 cites W1547961211 @default.
• W74156619 cites W1567817045 @default.
• W74156619 cites W1582726293 @default.
• W74156619 cites W1588147454 @default.
• W74156619 cites W1592367324 @default.
• W74156619 cites W1607718734 @default.
• W74156619 cites W1889350102 @default.
• W74156619 cites W1922574347 @default.
• W74156619 cites W1966684529 @default.
• W74156619 cites W1967127831 @default.
• W74156619 cites W1968041165 @default.
• W74156619 cites W1969244240 @default.
• W74156619 cites W1971420682 @default.
• W74156619 cites W1971443752 @default.
• W74156619 cites W1972526002 @default.
• W74156619 cites W1972757665 @default.
• W74156619 cites W1977905350 @default.
• W74156619 cites W1977937489 @default.
• W74156619 cites W1978206142 @default.
• W74156619 cites W1980220254 @default.
• W74156619 cites W1991639533 @default.
• W74156619 cites W1993825480 @default.
• W74156619 cites W1994175475 @default.
• W74156619 cites W1994220086 @default.
• W74156619 cites W1996287529 @default.
• W74156619 cites W1996659057 @default.
• W74156619 cites W1997106678 @default.
• W74156619 cites W1997877903 @default.
• W74156619 cites W1998185093 @default.
• W74156619 cites W1999748054 @default.
• W74156619 cites W2000421482 @default.
• W74156619 cites W2003343114 @default.
• W74156619 cites W2005118831 @default.
• W74156619 cites W2006595934 @default.
• W74156619 cites W2007737306 @default.
• W74156619 cites W2008501189 @default.
• W74156619 cites W2008849616 @default.
• W74156619 cites W2010045273 @default.
• W74156619 cites W2011291552 @default.
• W74156619 cites W2011356537 @default.
• W74156619 cites W2015339876 @default.
• W74156619 cites W2023242605 @default.
• W74156619 cites W2024133296 @default.
• W74156619 cites W2026170842 @default.
• W74156619 cites W2027065937 @default.
• W74156619 cites W2030085222 @default.
• W74156619 cites W2033407641 @default.
• W74156619 cites W2033637155 @default.
• W74156619 cites W2035104435 @default.
• W74156619 cites W2039602526 @default.
• W74156619 cites W2040113564 @default.
• W74156619 cites W2040987932 @default.
• W74156619 cites W2041512920 @default.
• W74156619 cites W2048559240 @default.
• W74156619 cites W2049927822 @default.
• W74156619 cites W2050876283 @default.
• W74156619 cites W2052059475 @default.
• W74156619 cites W2053271716 @default.
• W74156619 cites W2054107809 @default.
• W74156619 cites W2055300478 @default.
• W74156619 cites W2057027424 @default.
• W74156619 cites W2058301277 @default.
• W74156619 cites W2061293369 @default.
• W74156619 cites W2063846536 @default.
• W74156619 cites W2064519761 @default.
• W74156619 cites W2068103783 @default.
• W74156619 cites W2068615759 @default.
• W74156619 cites W2068866979 @default.
• W74156619 cites W2068960211 @default.
• W74156619 cites W2071305556 @default.
• W74156619 cites W2072546550 @default.
• W74156619 cites W2075523813 @default.
• W74156619 cites W2075856463 @default.
• W74156619 cites W2077092510 @default.
• W74156619 cites W2080224523 @default.
• W74156619 cites W2080517939 @default.
• W74156619 cites W2081018531 @default.
• W74156619 cites W2082552047 @default.
• W74156619 cites W2082871367 @default.
• W74156619 cites W2087203965 @default.
• W74156619 cites W2088742514 @default.
• W74156619 cites W2089362132 @default.
• W74156619 cites W2091402692 @default.
• W74156619 cites W2095817953 @default.
• W74156619 cites W2096458783 @default.
• W74156619 cites W2104709352 @default.
• W74156619 cites W2105981152 @default.

• next