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• W74162446 abstract "Complex peptides have continued to be lead structures in the search of drugs, especially those of microbial sources. In addition, the discovery of active peptides in animal sources including insects and mammals is advancing. As considerable progress has been achieved in the analysis of protein structure, the identification of targets and mechanisms of action is carried out at the molecular levels. For many purposes of structure-function studies the preparation and modification of complex peptides are required, and often chemical strategies are laborious or not available. Efforts have thus been conducted to make use of protein biocatalysts evolved in the producer organisms, exerting their catalytic powers under physiolgical conditions. Such enzymes permit the synthesis of complex metabolites like cyclic peptides in single pot sequential reactions starting from the direct precursor amino acids. In pharmaceutical research recent examples of bioengineering include the in vitro synthesis of immunomod-ulators of the cyclosporin-type and antihelminthics of the ennatin-type, as well as the in vivo synthesis of antifungals of the R106-type. The reasons for biocatalyst-assisted production are amongst others (1) the convenient and rapid access to small amounts of analogs, (2) the option to develop a later bioproduction of a certain analog since natural systems are exploited, and (3) the contribution of knowledge on these systems with a view to developing new systems for the generation of compound libraries." @default.
• W74162446 created "2016-06-24" @default.
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• W74162446 date "1997-01-01" @default.
• W74162446 modified "2023-09-30" @default.
• W74162446 title "Enzymatic generation of complex peptides" @default.
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• W74162446 doi "https://doi.org/10.1007/978-3-0348-8861-5_2" @default.
• W74162446 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9204682" @default.
• W74162446 hasPublicationYear "1997" @default.
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