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• W74241749 abstract "This chapter describes the role of the prefrontal cortex of the rat in learning and decision making. Depending on the authors reviews of prefrontal cortex (PFC) functions in rats have provided lists of behavioral deficiencies following damage of the PFC. They include deficient performance in various delay-type tasks, spatial tasks, inhibition, attention, along with abnormalities in social behavior. When rats with PFC damage are examined for their spatial learning skills in a Morris water maze, no impairments in spatial learning could be detected; however, when the task was changed from an allocentric one to a visual-cued one, rats with damage of the medial PFC were initially impaired. It is assumed that with prefrontal damage, it was more difficult to shift between tasks with different task demands. Evidence supporting this assumption has been obtained, when rats are trained either in a cheeseboard task, or a visual-cued version of that task. Transient inactivation of the medial PFC did not interfere with task acquisition. However, such an inactivation impaired learning when the rats were switched from one version of the task to the other one. It is tempting to relate these findings with the well-known deficiencies described in humans with PFC damage." @default.
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• W74241749 date "2000-01-01" @default.
• W74241749 modified "2023-10-12" @default.
• W74241749 title "Role of the prefrontal cortex of the rat in learning and decision making: effects of transient inactivation" @default.
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• W74241749 doi "https://doi.org/10.1016/s0079-6123(00)26010-x" @default.
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