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- W74242560 abstract "Secretory and membrane proteins are essential to all intercellular and most intracellular communication, and their precise locations and abundances are tightly regulated to maintain normal organismal physiology. Indeed, the majority of current drugs target secreted and membrane proteins, underscoring their central role in human biology. Our laboratory is working to develop a molecular level understanding of the pathways of secretory and membrane protein biosynthesis and metabolism. We are especially interested in the regulatory machinery controlling protein entry and insertion into the endoplasmic reticulum (ER), the site where nearly all secreted and membrane proteins are first made. Biochemical approaches are being employed to purify, identify, and functionally reconstitute the machinery underlying these basic cellular pathways. In parallel, the physiologic importance of regulating the metabolism of secretory and membrane proteins are being analyzed in cellular and whole animal models. We anticipate that a greater understanding of these basic cellular pathways will provide insight into the various diseases caused by problems in protein localization, folding, and processing." @default.
- W74242560 created "2016-06-24" @default.
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- W74242560 date "2008-03-01" @default.
- W74242560 modified "2023-09-27" @default.
- W74242560 title "The biosynthesis of secretory and membrane proteins" @default.
- W74242560 doi "https://doi.org/10.1096/fasebj.22.1_supplement.91.1" @default.
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