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- W74274511 abstract "Many cataractogenic stresses also induce endoplasmic reticulum (ER) stress in lens epithelial cells (LECs), which appears to be one of the universal inducers of cell death. In galactosemic rats, activation of ER stress results in the activation of the unfolded protein response (UPR)-dependent death pathway, production of reactive oxygen species (ROS), and cell death. All are induced and precede cataract formation. Cellular osmolytes such as 4-phenylbutyric acid (PBA), trimethylamine N-oxide (TMAO), and tauroursodeoxychoric acid (TUDCA) are known to suppress the induction of ER stress. We investigated whether these small molecules prevent cataract formation in galactose-fed rat lenses.Cultured LECs were treated with galactose and each cellular osmolyte. Sprague-Dawley rats were fed a 50% galactose chow for 15 days with or without cellular osmolyte treatment. Similarly, selenite was injected subcutaneously into rats with or without cellular osmolytes. Calcein AM and ethidium homodimer-1 (EthD) were used to detect live and dead cells, respectively. The cellular osmolytes, PBA, TMAO, and TUDCA were tested for their ability to suppress LEC death and cataract formation.Cellular osmolytes rescued cultured human LECs which were treated with the ER stressors. We administered these osmolytes either orally or by injection into galactosemic Sprague-Dawley rats. These rats had significantly reduced LEC death and partially delayed hypermature cataract formation. Since the UPR was not activated in cultured LECs treated with selenite, we used the selenite nuclear cataract as a UPR-independent death pathway control. In selenite-induced nuclear cataract in rats, cellular osmolytes did not prevent LEC death and did not alleviate cataract formation.These results further establish that ER stress and LEC death play a vital role in certain types of cataract formation. In addition, cellular osmolytes may be potential prophylactic drugs for some types of cataracts." @default.
- W74274511 created "2016-06-24" @default.
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- W74274511 date "2007-08-10" @default.
- W74274511 modified "2023-09-24" @default.
- W74274511 title "Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats." @default.
- W74274511 cites W132434727 @default.
- W74274511 cites W1488281450 @default.
- W74274511 cites W1505897004 @default.
- W74274511 cites W1518094649 @default.
- W74274511 cites W1639005451 @default.
- W74274511 cites W1875543681 @default.
- W74274511 cites W191207861 @default.
- W74274511 cites W1967883750 @default.
- W74274511 cites W1971087828 @default.
- W74274511 cites W1971534868 @default.
- W74274511 cites W1972308256 @default.
- W74274511 cites W1972799369 @default.
- W74274511 cites W1974314535 @default.
- W74274511 cites W1975405079 @default.
- W74274511 cites W1977982633 @default.
- W74274511 cites W1981173179 @default.
- W74274511 cites W1981589849 @default.
- W74274511 cites W1982534182 @default.
- W74274511 cites W1982555974 @default.
- W74274511 cites W1997811592 @default.
- W74274511 cites W1999207562 @default.
- W74274511 cites W2002813177 @default.
- W74274511 cites W2003110863 @default.
- W74274511 cites W2004329409 @default.
- W74274511 cites W2007811800 @default.
- W74274511 cites W2011112213 @default.
- W74274511 cites W2014023711 @default.
- W74274511 cites W2020437934 @default.
- W74274511 cites W2024421930 @default.
- W74274511 cites W2025518316 @default.
- W74274511 cites W2026591700 @default.
- W74274511 cites W2029112137 @default.
- W74274511 cites W2038763220 @default.
- W74274511 cites W2041559240 @default.
- W74274511 cites W2044092807 @default.
- W74274511 cites W2046040279 @default.
- W74274511 cites W2047591686 @default.
- W74274511 cites W2048456744 @default.
- W74274511 cites W2050107143 @default.
- W74274511 cites W2054128877 @default.
- W74274511 cites W2054246547 @default.
- W74274511 cites W2057145229 @default.
- W74274511 cites W2057969917 @default.
- W74274511 cites W2062023215 @default.
- W74274511 cites W2062145090 @default.
- W74274511 cites W2063333452 @default.
- W74274511 cites W2064752765 @default.
- W74274511 cites W2069141366 @default.
- W74274511 cites W2069565098 @default.
- W74274511 cites W2076205567 @default.
- W74274511 cites W2079852250 @default.
- W74274511 cites W2086372074 @default.
- W74274511 cites W2094274061 @default.
- W74274511 cites W2099579977 @default.
- W74274511 cites W2112286580 @default.
- W74274511 cites W2115633076 @default.
- W74274511 cites W2128635872 @default.
- W74274511 cites W2129695436 @default.
- W74274511 cites W2130661537 @default.
- W74274511 cites W2144892569 @default.
- W74274511 cites W2147336345 @default.
- W74274511 cites W2152522654 @default.
- W74274511 cites W2180169701 @default.
- W74274511 cites W2183734967 @default.
- W74274511 cites W2222634018 @default.
- W74274511 cites W2268076943 @default.
- W74274511 cites W2327164196 @default.
- W74274511 cites W2336047139 @default.
- W74274511 cites W2415422570 @default.
- W74274511 cites W2416954915 @default.
- W74274511 cites W2417147378 @default.
- W74274511 cites W2475086543 @default.
- W74274511 cites W2519667383 @default.
- W74274511 cites W2769999982 @default.
- W74274511 cites W3050186 @default.
- W74274511 cites W6214435 @default.
- W74274511 cites W877592711 @default.
- W74274511 cites W92329766 @default.
- W74274511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17768385" @default.
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