Matches in SemOpenAlex for { <https://semopenalex.org/work/W74276575> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W74276575 endingPage "8" @default.
- W74276575 startingPage "1213" @default.
- W74276575 abstract "The cellular form of FLICE-inhibitory protein (cFLIP) blocks death receptor-induced apoptosis and has been implicated in tumour progression. cFLIP interacts with caspase-8, thereby preventing activation of the caspase cascade. In this study we investigated the endogenous expression of cFLIP and caspase-8 in bladder carcinoma cells in relation to their sensitivity to death receptor-ligation.Apoptosis was induced by agonistic anti-CD95 mAbs or recombinant TRAIL and quantified by the TUNEL technique. The relative mRNA expression of cFLIP and caspase-8 was quantified by real-time PCR. Stable expression of cFLIP long (cFLIPL) was obtained by retroviral transduction.The relative ratio of cFLIP and caspase-8 was directly correlated to resistance to anti-CD95 or TRAIL-mediated apoptosis. Overexpression of cFLIPL shifted the responsiveness towards resistant status.cFLIP is an important determinant of susceptibility to death receptor-induced apoptosis in bladder carcinomas and could function as a prognostic marker for death receptor sensitivity in future immune therapy." @default.
- W74276575 created "2016-06-24" @default.
- W74276575 creator A5030860155 @default.
- W74276575 creator A5038124780 @default.
- W74276575 creator A5068235710 @default.
- W74276575 date "2003-06-25" @default.
- W74276575 modified "2023-09-27" @default.
- W74276575 title "High level of cFLIP correlates with resistance to death receptor-induced apoptosis in bladder carcinoma cells." @default.
- W74276575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12820373" @default.
- W74276575 hasPublicationYear "2003" @default.
- W74276575 type Work @default.
- W74276575 sameAs 74276575 @default.
- W74276575 citedByCount "19" @default.
- W74276575 countsByYear W742765752014 @default.
- W74276575 countsByYear W742765752015 @default.
- W74276575 countsByYear W742765752016 @default.
- W74276575 countsByYear W742765752019 @default.
- W74276575 crossrefType "journal-article" @default.
- W74276575 hasAuthorship W74276575A5030860155 @default.
- W74276575 hasAuthorship W74276575A5038124780 @default.
- W74276575 hasAuthorship W74276575A5068235710 @default.
- W74276575 hasConcept C170493617 @default.
- W74276575 hasConcept C190283241 @default.
- W74276575 hasConcept C203014093 @default.
- W74276575 hasConcept C3031857 @default.
- W74276575 hasConcept C31573885 @default.
- W74276575 hasConcept C48297814 @default.
- W74276575 hasConcept C502942594 @default.
- W74276575 hasConcept C54009773 @default.
- W74276575 hasConcept C54355233 @default.
- W74276575 hasConcept C55493867 @default.
- W74276575 hasConcept C62478195 @default.
- W74276575 hasConcept C81885089 @default.
- W74276575 hasConcept C86803240 @default.
- W74276575 hasConcept C95444343 @default.
- W74276575 hasConcept C98424977 @default.
- W74276575 hasConceptScore W74276575C170493617 @default.
- W74276575 hasConceptScore W74276575C190283241 @default.
- W74276575 hasConceptScore W74276575C203014093 @default.
- W74276575 hasConceptScore W74276575C3031857 @default.
- W74276575 hasConceptScore W74276575C31573885 @default.
- W74276575 hasConceptScore W74276575C48297814 @default.
- W74276575 hasConceptScore W74276575C502942594 @default.
- W74276575 hasConceptScore W74276575C54009773 @default.
- W74276575 hasConceptScore W74276575C54355233 @default.
- W74276575 hasConceptScore W74276575C55493867 @default.
- W74276575 hasConceptScore W74276575C62478195 @default.
- W74276575 hasConceptScore W74276575C81885089 @default.
- W74276575 hasConceptScore W74276575C86803240 @default.
- W74276575 hasConceptScore W74276575C95444343 @default.
- W74276575 hasConceptScore W74276575C98424977 @default.
- W74276575 hasIssue "2B" @default.
- W74276575 hasLocation W742765751 @default.
- W74276575 hasOpenAccess W74276575 @default.
- W74276575 hasPrimaryLocation W742765751 @default.
- W74276575 hasRelatedWork W1558416075 @default.
- W74276575 hasRelatedWork W1980525784 @default.
- W74276575 hasRelatedWork W2057746754 @default.
- W74276575 hasRelatedWork W2065338612 @default.
- W74276575 hasRelatedWork W2065929630 @default.
- W74276575 hasRelatedWork W2084363870 @default.
- W74276575 hasRelatedWork W2087041770 @default.
- W74276575 hasRelatedWork W2347673386 @default.
- W74276575 hasRelatedWork W2409526703 @default.
- W74276575 hasRelatedWork W2764177986 @default.
- W74276575 hasVolume "23" @default.
- W74276575 isParatext "false" @default.
- W74276575 isRetracted "false" @default.
- W74276575 magId "74276575" @default.
- W74276575 workType "article" @default.