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- W743009 abstract "Blood substitution with non-cellular fluids lowers blood viscosity and increases blood flow velocity, altering the oxygen delivering capacity of the microcirculation and the balance between diffusive and convective oxygen transport. When blood volume is maintained with either crystalloid or colloidal volume replacement, microcirculatory oxygen transport is adequate for red blood cell losses of the order of 60%. Hemoglobin solutions utilizing αα-hemoglobin show microvascular effects similar to those found with non-oxygen carrying solutions, but are reduced and the additional intrinsic oxygen carrying capacity of the blood/solution mixture is not manifested. Mathematical analysis of microvascular data shows that these effects are due to increased oxygen delivery capacity of the circulation, which increases arteriolar oxygenation. Ensuing metabolic autoregulatory responses lead to an oxygenation paradox resulting in vasoconstriction, impairment of functional capillary density, and increased microcirculatory metabolism, causing decreased tissue oxygenation. It is proposed that higher viscosity, left-shifted hemoglobin oxygen saturation solutions will fully oxygenate tissue." @default.
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- W743009 date "1995-01-01" @default.
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- W743009 title "Microcirculatory Consequences of Blood Substitution with αα-Hemoglobin" @default.
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- W743009 doi "https://doi.org/10.1007/978-1-4612-2576-8_11" @default.
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