Matches in SemOpenAlex for { <https://semopenalex.org/work/W74315666> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W74315666 endingPage "135.38" @default.
- W74315666 startingPage "135.38" @default.
- W74315666 abstract "Abstract Theiler’s murine encephalomyelitis virus (TMEV) is a mouse model of multiple sclerosis in which mice develop a chronic progressive demyelinating disease associated with a myelin- specific CD4+ T cell response. Our previous studies have demonstrated that the innate immune response directly affects the initiation and progression of demyelinating disease. We recently determined that the predominant innate immune cells infiltrating into the central nervous system (CNS) following TMEV infection are CD11b+Ly6C+ cells. CD11b+Ly6C+ cells are immature myeloid cells that exit the bone marrow without maturing. Thus, we wanted to determine the role of these cells in the immune response during demyelinating disease. CD11b+Ly6C+ cells isolated from the CNS during TMEV infection expressed high levels of IL-10 and iNOS and low levels of IL-12, and expressed low levels of costimulatory molecules and MHC class II. Most interestingly, CD11b+Ly6C+ cells isolated during TMEV- induced demyelinating disease suppressed CD4+ T cell responses against virus and myelin antigens. Furthermore, depletion of Ly6C+ cells during TMEV infection lead to increased expression of IFNγ, IL-12, and IL-17 in the CNS associated with increased T cell responses. These results suggest that these CD11b+Ly6C+ cells are myeloid derived suppressor cells that suppress T cell responses and affect the progression of demyelinating disease. This work was supported by the National Multiple Sclerosis Society Grant RG3625." @default.
- W74315666 created "2016-06-24" @default.
- W74315666 creator A5054544040 @default.
- W74315666 creator A5068884058 @default.
- W74315666 date "2010-04-01" @default.
- W74315666 modified "2023-10-16" @default.
- W74315666 title "CD11b+Ly6C+ cells, myeloid derived suppressor cells, affect T cell responses during demyelinating disease (135.38)" @default.
- W74315666 doi "https://doi.org/10.4049/jimmunol.184.supp.135.38" @default.
- W74315666 hasPublicationYear "2010" @default.
- W74315666 type Work @default.
- W74315666 sameAs 74315666 @default.
- W74315666 citedByCount "0" @default.
- W74315666 crossrefType "journal-article" @default.
- W74315666 hasAuthorship W74315666A5054544040 @default.
- W74315666 hasAuthorship W74315666A5068884058 @default.
- W74315666 hasConcept C121608353 @default.
- W74315666 hasConcept C136449434 @default.
- W74315666 hasConcept C169760540 @default.
- W74315666 hasConcept C171779818 @default.
- W74315666 hasConcept C179185449 @default.
- W74315666 hasConcept C203014093 @default.
- W74315666 hasConcept C2776090121 @default.
- W74315666 hasConcept C2777899865 @default.
- W74315666 hasConcept C2778531937 @default.
- W74315666 hasConcept C2778609137 @default.
- W74315666 hasConcept C2778814158 @default.
- W74315666 hasConcept C2779282312 @default.
- W74315666 hasConcept C2780640218 @default.
- W74315666 hasConcept C529278444 @default.
- W74315666 hasConcept C54355233 @default.
- W74315666 hasConcept C55721878 @default.
- W74315666 hasConcept C86803240 @default.
- W74315666 hasConcept C8891405 @default.
- W74315666 hasConceptScore W74315666C121608353 @default.
- W74315666 hasConceptScore W74315666C136449434 @default.
- W74315666 hasConceptScore W74315666C169760540 @default.
- W74315666 hasConceptScore W74315666C171779818 @default.
- W74315666 hasConceptScore W74315666C179185449 @default.
- W74315666 hasConceptScore W74315666C203014093 @default.
- W74315666 hasConceptScore W74315666C2776090121 @default.
- W74315666 hasConceptScore W74315666C2777899865 @default.
- W74315666 hasConceptScore W74315666C2778531937 @default.
- W74315666 hasConceptScore W74315666C2778609137 @default.
- W74315666 hasConceptScore W74315666C2778814158 @default.
- W74315666 hasConceptScore W74315666C2779282312 @default.
- W74315666 hasConceptScore W74315666C2780640218 @default.
- W74315666 hasConceptScore W74315666C529278444 @default.
- W74315666 hasConceptScore W74315666C54355233 @default.
- W74315666 hasConceptScore W74315666C55721878 @default.
- W74315666 hasConceptScore W74315666C86803240 @default.
- W74315666 hasConceptScore W74315666C8891405 @default.
- W74315666 hasIssue "1_Supplement" @default.
- W74315666 hasLocation W743156661 @default.
- W74315666 hasOpenAccess W74315666 @default.
- W74315666 hasPrimaryLocation W743156661 @default.
- W74315666 hasRelatedWork W1541403708 @default.
- W74315666 hasRelatedWork W165035876 @default.
- W74315666 hasRelatedWork W19326740 @default.
- W74315666 hasRelatedWork W1988751579 @default.
- W74315666 hasRelatedWork W1991670423 @default.
- W74315666 hasRelatedWork W2081395451 @default.
- W74315666 hasRelatedWork W2092685741 @default.
- W74315666 hasRelatedWork W4313388172 @default.
- W74315666 hasRelatedWork W4317715430 @default.
- W74315666 hasRelatedWork W600795284 @default.
- W74315666 hasVolume "184" @default.
- W74315666 isParatext "false" @default.
- W74315666 isRetracted "false" @default.
- W74315666 magId "74315666" @default.
- W74315666 workType "article" @default.