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• W74337203 abstract "Programmed cell death (PCD) is an integral part of many developmental processes. In vertebrates little is yet known on the patterns of PCD and its role during the early phases of development, when embryonic tissue layers migrate and pattern formation takes place. We describe the spatio-temporal patterns of cell death during early Xenopus development, from fertilization to the tadpole stage (stage 35/36). Cell death was analyzed by a whole-mount in situ DNA end-labeling technique (the TUNEL protocol), as well as by serial sections of paraffin-embedded TUNEL-stained embryos. The first cell death was detected during gastrulation, and as development progressed followed highly dynamic and reproducible patterns, strongly suggesting it is an important component of development at these stages. The detection of PCD during neural induction, neural plate patterning, and later during the development of the nervous system highlights the role of PCD throughout neurogenesis. Additionally, high levels of cell death were detected in the developing tail and sensory organs. This is the first detailed description of PCD throughout early development of a vertebrate, and provides the basis for further studies on its role in the patterning and morphogenesis of the embryo." @default.
• W74337203 created "2016-06-24" @default.
• W74337203 creator A5066167912 @default.
• W74337203 creator A5083351997 @default.
• W74337203 date "1998-11-01" @default.
• W74337203 modified "2023-10-09" @default.
• W74337203 title "Programmed Cell Death duringXenopusDevelopment: A Spatio-temporal Analysis" @default.
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• W74337203 doi "https://doi.org/10.1006/dbio.1998.9028" @default.
• W74337203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9806771" @default.
• W74337203 hasPublicationYear "1998" @default.
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