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• W74384003 abstract "OF THESIS INCREASE OF BASAL OXIDATIVE STRESS LEVELS AND IMPAIRMENT OF HEME OXYGENASE-1/BILIVERDIN REDUCTASE POST-TRANSLATIONAL MODIFICATION BY THE DEFECT OF PARKINSON-RELATED GENE OF PINK1 Parkinson disease (PD) is the most common movement disorder and the second most common neurodegenerative disease. PINK1, PTEN-induced kinase 1, functions as a serine/threonine kinase as well as a protector of mitochondrial function. Mutations in PINK1 gene result in either mitochondria dysfunction or disruption of kinase signaling pathways involved in the pathogenesis of PD. In this thesis, oxidative stress levels were examined in the brain of PINK1 knockout mice, and also how heme oxygenase-1 and biliverdin reductase are affected in brain of PINK1 knockout mice. In addition, posttranslational modifications are a way to control the behavior of proteins, so posttranslational modifications of the brain of PINK1 knockout mice, including both oxidative modification and phosphorylative modification, were examined." @default.
• W74384003 created "2016-06-24" @default.
• W74384003 creator A5041744208 @default.
• W74384003 date "2014-01-01" @default.
• W74384003 modified "2023-09-27" @default.
• W74384003 title "INCREASE OF BASAL OXIDATIVE STRESS LEVELS AND IMPAIRMENT OF HEME OXYGENASE-1/BILIVERDIN REDUCTASE POST-TRANSLATIONAL MODIFICATION BY THE DEFECT OF PARKINSON-RELATED GENE OF PINK1" @default.
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