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- W744235106 startingPage "e0131392" @default.
- W744235106 abstract "The recognition that oxidative stress is a major component of several chronic diseases has engendered numerous trials of antioxidant therapies with minimal or no direct benefits. Nanomolar quantities of nitric oxide released into the circulation by pharmacologic stimulation of eNOS have antioxidant properties but physiologic stimulation as through increased pulsatile shear stress of the endothelium has not been assessed. The present study utilized a non-invasive technology, periodic acceleration (pGz) that increases pulsatile shear stress such that upregulation of cardiac eNOS occurs, We assessed its efficacy in normal mice and mouse models with high levels of oxidative stress, e.g. Diabetes type 1 and mdx (Duchene Muscular Dystrophy). pGz increased protein expression and upregulated eNOS in hearts. Application of pGz was associated with significantly increased expression of endogenous antioxidants (Glutathioneperoxidase-1(GPX-1), Catalase (CAT), Superoxide, Superoxide Dismutase 1(SOD1). This led to an increase of total cardiac antioxidant capacity along with an increase in the antioxidant response element transcription factor Nrf2 translocation to the nucleus. pGz decreased reactive oxygen species in both mice models of oxidative stress. Thus, pGz is a novel non-pharmacologic method to harness endogenous antioxidant capacity." @default.
- W744235106 created "2016-06-24" @default.
- W744235106 creator A5003351212 @default.
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- W744235106 date "2015-07-02" @default.
- W744235106 modified "2023-10-08" @default.
- W744235106 title "Antioxidant Properties of Whole Body Periodic Acceleration (pGz)" @default.
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- W744235106 doi "https://doi.org/10.1371/journal.pone.0131392" @default.
- W744235106 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4489838" @default.
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