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- W744356144 abstract "Prostaglandin (PG) E2 produces a broad range of physiological and pharmacological actions in diverse tissues through specific receptors on plasma membranes for maintenance of local homeostasis in the body1. PGE receptors are pharmacologically divided into four subtypes, EP1, EP2, EP3 and EP4, on the basis of their responses to various agonists and antagonists2. Among these subtypes, the EP3 receptor has been most well characterized and suggested to be involved in the diverse actions of PGE2, such as contraction of the uterus, and inhibition of gastric acid secretion, neurotransmitter release, lipolysis in adipose tissue, sodium and water reabsorption in kidney tubules, and modulation of catecholamine release from adrenal chromaffin cells3. Although EP3 receptor-mediated actions are believed to be mediated by inhibition of adenylate cyclase, the dose-response curve and potency of PGE2 vary with the tissues, implying heterogeneity of EP3 receptors. Furthermore, some of the PGE2 actions appears to be mediated by another second messenger pathway. These different properties of the EP3 imply heterogeneity of this type receptor. We have recently cloned three isoforms of the mouse EP3 receptor with different carboxy-terminal tails, which are produced through alternative splicing4. To assess the role of the carboxy-terminal tails of the EP3 receptor in coupling to G proteins, we constructed a mutated EP3 receptor, T-335, in which the carboxy-terminal tail was truncated at the alternative splicing site. We report here that the three isoforms differ in agonist-independent constitutive Gi activity and agonist-dependent Gs activity." @default.
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- W744356144 date "1997-01-01" @default.
- W744356144 modified "2023-09-26" @default.
- W744356144 title "Three Isoforms of the Prostaglandin E Receptor EP3 Subtype Different in Agonist-Independent Constitutive Gi Activity and Agonist-Dependent Gs Activity" @default.
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- W744356144 doi "https://doi.org/10.1007/978-1-4899-1810-9_51" @default.
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