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- W744363486 abstract "Here, we have characterized the first known auto-inflammatory disease caused by interleukin-18 (IL-18). This is due to a point mutation in the gene Wdr1 , which is required for disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Mice homozygous for this mutation ( Wdr1 rd / rd ) develop severe autoinflammation in the ears and tail due to an intracellular build up of polymerized actin. The serum IL-18 level was significantly elevated in Wdr1 rd / rd mice, compared to littermate controls. Processing and secretion of IL-18 and IL-1β is induced by caspase-1 via activation of the inflammasome complex. Importantly, a delayed onset of the disease was seen in Wdr1 rd / rd mice lacking caspase-1, the inflammasome adaptor ASC or IL-18 itself. In contrast, the time of onset and severity of the inflammatory disease was not altered by a deficiency of IL-1R, G-CSF, interferon γ (IFNγ) or tumor necrosis factor α (TNFα), suggesting that the inflammatory disease was driven by an IL-18 specific inflammasome. Furthermore, we are able to show ex vivo and in vivo, that this IL-18 production specifically comes from monocytes, but not mature macrophages. Overall, our data reveal the mechanism and biological basis of a mouse model of spontaneous sterile inflammatory disease driven by IL-18 but not IL-1." @default.
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- W744363486 date "2014-11-01" @default.
- W744363486 modified "2023-09-27" @default.
- W744363486 title "126" @default.
- W744363486 doi "https://doi.org/10.1016/j.cyto.2014.07.133" @default.
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