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- W74441456 endingPage "44" @default.
- W74441456 startingPage "1" @default.
- W74441456 abstract "The reviewed literature leaves us with an impression of the cellular interchange of Glu and its precursors and metabolites (Fig.. 2) that is somewhat different from the classical idea of the ‘glutamine“ cycle with its near-stoichiometric exchange of Glu and glutamine between neurons and astrocytes. (1) Glu is synthesized from glutamine, as previously thought, but also from neuronal precursors supplied by neuronal pyruvate carboxylation. (2) Transmitter Glu is mostly taken up into astrocytes for conversion to glutamine, but an unknown fraction is metabolized by the astrocytic TCA cycle, either fully to CO2 and water, or only partially, to malate which is converted to pyruvate and hence lactate. (3) Uptake of Glu into astrocytes stimulates astrocytic uptake of serum glucose and export of lactate to the extracellular fluid. (4) Lactate, whether formed from transmitter Glu or serum glucose, may increase regional cerebral blood flow and act as a main neuronal energy substrate. (5) Glutamine is shunted to neurons where it to a large extent is metabolized to CO2 and water and, possibly to a lesser extent, is converted to transmitter Glu. (6) The uptake processes related to the handling of transmitter Glu and glutamine together with the formation of glutamine cause the expenditure of % of the total energy of the serum glucose taken up by the brain." @default.
- W74441456 created "2016-06-24" @default.
- W74441456 creator A5034285165 @default.
- W74441456 creator A5041914438 @default.
- W74441456 creator A5064830191 @default.
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- W74441456 date "2000-01-01" @default.
- W74441456 modified "2023-09-30" @default.
- W74441456 title "Chapter 1 Biochemistry and anatomy of transmitter glutamate" @default.
- W74441456 cites W111736103 @default.
- W74441456 cites W1489246530 @default.
- W74441456 cites W1491463220 @default.
- W74441456 cites W1508710284 @default.
- W74441456 cites W1510842361 @default.
- W74441456 cites W1514666668 @default.
- W74441456 cites W1517853766 @default.
- W74441456 cites W1518488422 @default.
- W74441456 cites W1521108077 @default.
- W74441456 cites W1541602774 @default.
- W74441456 cites W1541615960 @default.
- W74441456 cites W1555302630 @default.
- W74441456 cites W1564717701 @default.
- W74441456 cites W1585218706 @default.
- W74441456 cites W1593745576 @default.
- W74441456 cites W1599493604 @default.
- W74441456 cites W1655827168 @default.
- W74441456 cites W1671279920 @default.
- W74441456 cites W1671926542 @default.
- W74441456 cites W1759490885 @default.
- W74441456 cites W1772857860 @default.
- W74441456 cites W1880718918 @default.
- W74441456 cites W1888179590 @default.
- W74441456 cites W1911836937 @default.
- W74441456 cites W1916190008 @default.
- W74441456 cites W1947652441 @default.
- W74441456 cites W1955955709 @default.
- W74441456 cites W1957209685 @default.
- W74441456 cites W1963569120 @default.
- W74441456 cites W1965162244 @default.
- W74441456 cites W1965372184 @default.
- W74441456 cites W1965591048 @default.
- W74441456 cites W1966146114 @default.
- W74441456 cites W1967063692 @default.
- W74441456 cites W1967192722 @default.
- W74441456 cites W1967224834 @default.
- W74441456 cites W1968419639 @default.
- W74441456 cites W1969277758 @default.
- W74441456 cites W1969689529 @default.
- W74441456 cites W1970000810 @default.
- W74441456 cites W1971390306 @default.
- W74441456 cites W1971627924 @default.
- W74441456 cites W1971866692 @default.
- W74441456 cites W1972150073 @default.
- W74441456 cites W1973294504 @default.
- W74441456 cites W1973620174 @default.
- W74441456 cites W1976228088 @default.
- W74441456 cites W1976236800 @default.
- W74441456 cites W1976256462 @default.
- W74441456 cites W1976674357 @default.
- W74441456 cites W1976782467 @default.
- W74441456 cites W1976989422 @default.
- W74441456 cites W1977005382 @default.
- W74441456 cites W1977451474 @default.
- W74441456 cites W1977621923 @default.
- W74441456 cites W1978226965 @default.
- W74441456 cites W1978604592 @default.
- W74441456 cites W1979136169 @default.
- W74441456 cites W1979153562 @default.
- W74441456 cites W1979511946 @default.
- W74441456 cites W1980480853 @default.
- W74441456 cites W1980489779 @default.
- W74441456 cites W1980578192 @default.
- W74441456 cites W1980979304 @default.
- W74441456 cites W1981078032 @default.
- W74441456 cites W1982126071 @default.
- W74441456 cites W1983108223 @default.
- W74441456 cites W1984446252 @default.
- W74441456 cites W1984983378 @default.
- W74441456 cites W1985578899 @default.
- W74441456 cites W1986036334 @default.
- W74441456 cites W1986129914 @default.
- W74441456 cites W1986343952 @default.
- W74441456 cites W1986393847 @default.
- W74441456 cites W1987040923 @default.
- W74441456 cites W1987080089 @default.
- W74441456 cites W1987191167 @default.
- W74441456 cites W1987548555 @default.
- W74441456 cites W1987893556 @default.
- W74441456 cites W1989189901 @default.
- W74441456 cites W1990368783 @default.
- W74441456 cites W1991566731 @default.
- W74441456 cites W1991954431 @default.
- W74441456 cites W1992417460 @default.
- W74441456 cites W1994323359 @default.
- W74441456 cites W1994616281 @default.
- W74441456 cites W1995570556 @default.
- W74441456 cites W1995591736 @default.
- W74441456 cites W1996785904 @default.