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- W7444607 abstract "Cancer is one of the principal causes of death in the world and its therapy researchleads a strong, but nowadays without great results, interest by scientific community.The treatment given for cancer is highly variable and dependent on a number offactors including the type, location and amount of disease and the health status of thepatient (surgery, radiation, chemotherapy, hormonal treatment, antibodies,immunotherapy) but the discover of compounds able to kill selectively the affectedcells is the main goal for medicinal chemists. With the aim to decrease their toxicityoften the different types of treatment are used in combination, either simultaneouslyor sequentially.In this thesis, the design, synthesis and biological evaluation of two different kindsof anticancer compounds are described.The synthesis of novel aminobisphosphonates compounds leads to the developmentof new molecules which induce the immune system, enhancing its antitumor effect.This project is involved in immunotherapy field, a promising and no toxic anticancertherapy approach.Moreover, the synthesis of new natural stilbenes related compounds, involved in thecytotoxic chemotherapy field, lead us to develop a set of high activity molecules,which are promising for further pre-clinical and clinical studies." @default.
- W7444607 created "2016-06-24" @default.
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- W7444607 date "2009-03-23" @default.
- W7444607 modified "2023-09-27" @default.
- W7444607 title "NOVEL ANTITUMOR AGENTSSTRUCTURALLY RELATED TOAMINOBISPHOSPHONATES AND STILBENES" @default.
- W7444607 hasPublicationYear "2009" @default.
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