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- W74491618 abstract "To determine the complement of proteins that make up the dopamine receptor (DAR) signalplex, we have employed a co-immunoprecipitation assay for DARs coupled with mass spectrometry sequencing. Interacting proteins identified through these experiments include the Na+/K+-ATPase (NKA), a finding confirmed by Western analysis and reverse co-immunoprecipitation experiments, which revealed specific D1 and D2 DAR interactions with NKA. To determine the impact of NKA on DAR function, biological assays were conducted in the presence of enhanced levels of NKA in HEK293 cells. In this system, over-expression of NKA yields a dramatic decrease in total D1 and D2 DAR expression, with a concomitant functional decrease in DAR-mediated regulation of cAMP production. Interestingly, pharmacological inhibition of either over-expressed or endogenous NKA with ouabain enhanced DAR activity, as measured by cAMP production. Furthermore, over-expression of DARs also impacts NKA function, causing a decrease in endogenous NKA activity as measured by 86Rb uptake. Current studies are underway to determine the consequence of receptor stimulation or desensitization on DAR-NKA interactions. Whether this interaction is direct or indirect will also be investigated. These preliminary data indicate that DARs and NKA can reciprocally regulate one another, providing a control mechanism for both DAR signaling and cellular ion balance. Support contributed by NIGMS PRAT program (LAH) and NINDS intramural program." @default.
- W74491618 created "2016-06-24" @default.
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- W74491618 date "2007-04-01" @default.
- W74491618 modified "2023-10-18" @default.
- W74491618 title "Reciprocal modulation of function between the D 1 and D 2 dopamine receptors and the Na + /K + ‐ATPase, a novel member of the dopamine receptor signalplex" @default.
- W74491618 doi "https://doi.org/10.1096/fasebj.21.5.a423" @default.
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