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• W74497105 abstract "Breast cancer is a multifactorial, clinically, and, quite probably, etiologically heterogeneous disease that manifests itself only after a long and largely obscure latency period. Breast cancer is also a systemic disease, responding to and causing changes in the host well beyond the sites of cancer growth per se. Given these complexities, it is not surprising that, despite the efforts of numerous investigators, the field of breast cancer immunology has yet to have a major impact on either the understanding or control of the disease. Perhaps this lamentable situation results, at least in part, from the majority of research in breast cancer immunology being directed toward investigations of what — in terms of natural history — are actually the later stages of the disease, that is, the ‘earliest’ evidence of clinical cancer. Perhaps by this time, the momentum of the neoplastic process has reached a stage where it blunts the finely regulated inflammatory and immune systems to the extent that whatever immune growth-regulatory influences have been operative during preclinical cancer development are swamped by the combined effects of the disease and its treatment. The purposes of this review are to summarize the current state of knowledge about breast cancer immunology and to present our perspective on the most promising areas of future research. We have not attempted to be all inclusive in the literature reviewed and apologize to any colleagues whose work is slighted." @default.
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• W74497105 date "1996-01-01" @default.
• W74497105 modified "2023-09-23" @default.
• W74497105 title "Breast cancer immunology" @default.
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• W74497105 doi "https://doi.org/10.1007/978-1-4613-1259-8_19" @default.
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