Matches in SemOpenAlex for { <https://semopenalex.org/work/W7455686> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W7455686 endingPage "899" @default.
- W7455686 startingPage "894" @default.
- W7455686 abstract "Introduction: IgA nephritis (IgAN) is the most common glomerulonephritis worldwide. We aim to genotype SNPs (single nucleotide polymorphisms) genomewide in patients with IgAN to search for genetic clues to its aetiology. Materials and Methods: Genotyping for 10,204 SNPs genomewide was done with the Gene Chip Human Mapping 10K Microarray (Affymetrix). Twenty-eight patients with IgAN and 30 normal subjects were screened and analysed for differences in genotype frequency, allele frequency and heterozygosity reduction. Results: Among the most significantly associated SNPs, 48 SNPs were found mapping directly to the intron of 42 genes that localised in 13 somatic chromosomes and chromosome X. Genotype distribution of these SNPs did not deviate from the Hardy-Weinberg equilibrium in normal subjects. The most significantly associated gene, glial cells missing homolog 1 (GCM, 2 =13.05, P = 0.000) is a transcription factor mapped to 6p12.2. GCM1 reported decreased in placenta of patients with pre-eclampsia. The second gene, Tenascin-R (TNR, 2 = 9.85, P = 0.002) is a glycoprotein and extra-cellular matrix component mapped to 1q25.1. Tenascin-R was associated with motor coordination impairment and enhanced anxiety profile in deficient mice. Interestingly, Triadin (TRDN, 2 = 9.16, P = 0.01) is an integral membrane protein mapped to 6q22.31 within the IgAN1 locus. Triadin was shown to participate in cardiac myocyte arrhythemia. However, there is no published study of these genes in IgAN. Conclusion: Forty-two associated genes (particularly GCM1, TNR and TRDN) are identified as possible susceptibility or marker genes for IgAN. Knowledge of their mesangial expression and binding capacity for IgA-containing complexes may help elucidate the pathogenesis of IgAN. Key words: Glomerulonephritis, IgA nephritis" @default.
- W7455686 created "2016-06-24" @default.
- W7455686 creator A5032182958 @default.
- W7455686 creator A5038421028 @default.
- W7455686 creator A5059359253 @default.
- W7455686 creator A5065773926 @default.
- W7455686 creator A5068644879 @default.
- W7455686 date "2000-10-15" @default.
- W7455686 modified "2023-09-27" @default.
- W7455686 title "Parallel Genotyping of 10,204 Single Nucleotide Polymorphisms to Screen for Susceptible Genes for IgA Nephropathy" @default.
- W7455686 cites W1492667645 @default.
- W7455686 cites W1500261682 @default.
- W7455686 cites W1964920299 @default.
- W7455686 cites W1967560965 @default.
- W7455686 cites W1969109045 @default.
- W7455686 cites W1983179229 @default.
- W7455686 cites W2001414407 @default.
- W7455686 cites W2009484631 @default.
- W7455686 cites W2014571143 @default.
- W7455686 cites W2045586900 @default.
- W7455686 cites W2050136200 @default.
- W7455686 cites W2053949930 @default.
- W7455686 cites W2075701003 @default.
- W7455686 cites W2092965972 @default.
- W7455686 cites W2104261859 @default.
- W7455686 cites W2106582531 @default.
- W7455686 cites W2112473106 @default.
- W7455686 cites W2114847949 @default.
- W7455686 cites W2116498325 @default.
- W7455686 cites W2166833206 @default.
- W7455686 cites W4233406113 @default.
- W7455686 cites W4249536216 @default.
- W7455686 doi "https://doi.org/10.47102/annals-acadmedsg.v38n10p894" @default.
- W7455686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19890582" @default.
- W7455686 hasPublicationYear "2000" @default.
- W7455686 type Work @default.
- W7455686 sameAs 7455686 @default.
- W7455686 citedByCount "8" @default.
- W7455686 countsByYear W74556862012 @default.
- W7455686 countsByYear W74556862013 @default.
- W7455686 countsByYear W74556862014 @default.
- W7455686 countsByYear W74556862019 @default.
- W7455686 countsByYear W74556862022 @default.
- W7455686 crossrefType "journal-article" @default.
- W7455686 hasAuthorship W7455686A5032182958 @default.
- W7455686 hasAuthorship W7455686A5038421028 @default.
- W7455686 hasAuthorship W7455686A5059359253 @default.
- W7455686 hasAuthorship W7455686A5065773926 @default.
- W7455686 hasAuthorship W7455686A5068644879 @default.
- W7455686 hasBestOaLocation W74556861 @default.
- W7455686 hasConcept C104317684 @default.
- W7455686 hasConcept C135763542 @default.
- W7455686 hasConcept C153209595 @default.
- W7455686 hasConcept C177580304 @default.
- W7455686 hasConcept C197754878 @default.
- W7455686 hasConcept C31467283 @default.
- W7455686 hasConcept C54355233 @default.
- W7455686 hasConcept C69991583 @default.
- W7455686 hasConcept C86803240 @default.
- W7455686 hasConceptScore W7455686C104317684 @default.
- W7455686 hasConceptScore W7455686C135763542 @default.
- W7455686 hasConceptScore W7455686C153209595 @default.
- W7455686 hasConceptScore W7455686C177580304 @default.
- W7455686 hasConceptScore W7455686C197754878 @default.
- W7455686 hasConceptScore W7455686C31467283 @default.
- W7455686 hasConceptScore W7455686C54355233 @default.
- W7455686 hasConceptScore W7455686C69991583 @default.
- W7455686 hasConceptScore W7455686C86803240 @default.
- W7455686 hasIssue "10" @default.
- W7455686 hasLocation W74556861 @default.
- W7455686 hasLocation W74556862 @default.
- W7455686 hasOpenAccess W7455686 @default.
- W7455686 hasPrimaryLocation W74556861 @default.
- W7455686 hasRelatedWork W1509356867 @default.
- W7455686 hasRelatedWork W1663907732 @default.
- W7455686 hasRelatedWork W1901150897 @default.
- W7455686 hasRelatedWork W1983117759 @default.
- W7455686 hasRelatedWork W1986957655 @default.
- W7455686 hasRelatedWork W2015172781 @default.
- W7455686 hasRelatedWork W2049974637 @default.
- W7455686 hasRelatedWork W2100122972 @default.
- W7455686 hasRelatedWork W2125326038 @default.
- W7455686 hasRelatedWork W2985241277 @default.
- W7455686 hasVolume "38" @default.
- W7455686 isParatext "false" @default.
- W7455686 isRetracted "false" @default.
- W7455686 magId "7455686" @default.
- W7455686 workType "article" @default.