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• W7456409 abstract "In the recent decade the quan-titative and qualitative state of environmental mutagenic factors has altered significantly. Their negative impact on the gene pool of all liv-ing creatures has increased, which can result in the augmented mutagenic pressure on human populations [5]. Provided that unrestrained en-vironmental pollution takes place, the future unfolds a new genetic disaster along with an ecologic one. This requires elaboration and im-plementation of the environmental ecological monitoring, which aims to organize systemic observation of the biosphere changes. Taking into account the abovementioned, the urgent problem of ecological genetics is spotlighted, that is systemic observation of the genetic as-pects of environmental pollution and forecast-ing far-reaching effects of the mutagenic pres-sure influence on the living nature state and human genetic apparatus. These changes of the human genetic apparatus cause cell function impairment, which could trigger rapid ageing of the organism on the whole. Overwhelming majority of countries have reflected a tenden-cy towards prolonged life expectancy of their population, which leads to increased number of senile people, who aspire to protract the normal physical, social and psychological activity span as much as possible [3].Therefore an anti-ageing campaign elaboration, based on profound knowledge of life expectancy and longevity formation mechanisms is an absolute medical priority. Contemporary notions imply ageing is a deceleration, depression and loss of physiological functions of the organism in concomitance with an increased frequency of oncologic and degenerative diseases [4]. On the cellular level ageing is based on the cellular impairment accumulation, survival mechanisms depression, cell and tissue regeneration abatement. Molecular mechanisms of ageing comprise mutations, DNA replication and reparation impairment, protein glycolysis, transverse macromolecular sutures formation, oxidative stress, methylation, etc [1].Results of twins’ longevity investigation proved that life expectancy inheritance is of 30-40% [9]. Centenarians’ descendants were four times more likely to live up to 85 years and more, than those whose progenitors died in the age of 73 [11]. Though longevity is to a large extent predisposed by genetic features, the role of exogenic ones, such as mode of life and nutrition, is of a vital importance. For that reason identification of the genes responsible for life expectancy and development of age-related diseases is essential as well as identification of genes and environmental factors interrelation [2]. It is required that genetic polymorphism of various populations is taken into account [10]. Contribution of genetic divergences proportions on all levels of citizens of the Globe hierarchy structure investigation of portion data indicate that its lion’s share is due to intrapopulation variability level. This explains considerable divergences in people’s response to the pressure of the same environment [7]. Thus variability level inside the group is essential to absolutely optimal to define genetic differentiation of population according to environmental factors influence." @default.
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• W7456409 date "2010-01-01" @default.
• W7456409 modified "2023-09-23" @default.
• W7456409 title "Demographic characteristic of the human population in different ecological regions of Precarpathia" @default.
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