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- W74594580 abstract "The success of the bacterial short-term tests for the detection of mutagenic and potentially carcinogenic chemicals accentuated the need for a simple and quick mammalian in vivo screening system, which could be used in parallel to the bacterial assay in order to assess the probability of such an effect in mammals. Most mammalian in vivo systems make use of a singular genetic endpoint, namely chromosome breakage in one or another form. However, as experiments with Drosophila have shown (Vogel and Leigh, 1975), chromosome breakage is an insensitive indicator of genetic damage, and an endpoint common to chromosome breakage and other genetic effects would thus be desirable. An example of such a common endpoint could be the covalent binding of a chemical to DNA." @default.
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- W74594580 date "1981-01-01" @default.
- W74594580 modified "2023-09-26" @default.
- W74594580 title "The Testicular DNA-Synthesis Inhibition Test (DSI Test)" @default.
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- W74594580 doi "https://doi.org/10.1007/978-1-4612-5847-6_10" @default.
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