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- W745961 abstract "Abstract Hot-water (100℃) and cold-water (4℃) extracts of Taraxacum officinale root were assessed for the effects of innate and adaptive immune responses in mice. Hot water extracts (TO-100) and cold water extracts (TO-4) did not affect the viability of macrophages at concentrations below to 18 ㎎/㎖ and 8 ㎎/㎖, respectively. The thioglycollate-induced macrophages cultured with TO-100 and TO-4 produced a significantly higher quantity of various cytokines, such as IL-6 and IL-12, than those treated with medium. This shows that the extracts potently stimulated the innate immune response. When mice were subcutaneously immunized(sc) with OVA+FIA (Freund's incomplete adjuvant)-emulsified TO-100, TO-100 did not affect the production of IgE, but enhanced the production of IgG1, IgG2a and IgG2b. The culture supernatant obtained from the splenocytes of mice treated with OVA+FIA-emulsified TO-100 also evidenced elevated levels of both OVA-specific Th1-type (IFN-γ) and Th2-type cytokines (IL-4, IL-6 and IL-10). These results suggested that TO-100 can modulate the immune responses to allergens in mice. Key words: Taraxacum officinale, innate and adaptive immunity, antibody, cytokine." @default.
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- W745961 date "2008-01-01" @default.
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- W745961 title "Effect of Water Extracts from Root of Taraxacum officinale on Innate and Adaptive Immune Responses in Mice" @default.
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