FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W746630715> ?p ?o ?g. }

• W746630715 endingPage "10" @default.
• W746630715 startingPage "3803" @default.
• W746630715 abstract "Ovarian cancer is the fourth most ordinary cause of cancer-related deaths in women. In recent, combination chemotherapy with carboplatin and docetaxel was developed as first-line drug to treat ovarian carcinoma. However, the detailed molecular mechanism, which accounts for the cells to apoptosis induced by administration of carboplatin and docetaxel, was unrecognized. In present study, we provide the mechanistic link between mixture of carboplatin plus docetaxel and its anticancer activity. Primarily, a majority of 30 cancer-related long non-coding RNA (lncRNA) showed differential alteration in carboplatin-docetaxel-treated 3AO cells. Among six up-regulating lncRNAs, we screened out carboplatin-docetaxel-induced lncRNA PVT1 which may be a central downstream target of carboplatin plus docetaxel because expression of PVT1 positively correlates with anticancer action of carboplatin plus docetaxel. Besides, p53 and tissue inhibitor of matrix metalloproteinases-1 (TIMP1) were mediated by lncRNA PVT1, which may explain partially the anticancer activity of lncRNA PVT1. Collectively, we have identified a potential mechanism by which PVT1 regulated by carboplatin plus docetaxel contributes to the carboplatin-docetaxel-induced anticancer action in ovarian cancer. These discoveries also give proof of the potential of PVT1 as significant downstream targets for therapeutic intervention in ovarian cancer." @default.
• W746630715 created "2016-06-24" @default.
• W746630715 creator A5038829016 @default.
• W746630715 creator A5049763932 @default.
• W746630715 creator A5065771969 @default.
• W746630715 date "2015-01-01" @default.
• W746630715 modified "2023-10-16" @default.
• W746630715 title "Carboplatin-docetaxel-induced activity against ovarian cancer is dependent on up-regulated lncRNA PVT1." @default.
• W746630715 cites W1963867594 @default.
• W746630715 cites W1999746344 @default.
• W746630715 cites W2015519364 @default.
• W746630715 cites W2028363781 @default.
• W746630715 cites W2030526529 @default.
• W746630715 cites W2039816251 @default.
• W746630715 cites W2045086385 @default.
• W746630715 cites W2060618478 @default.
• W746630715 cites W2061427860 @default.
• W746630715 cites W2086026895 @default.
• W746630715 cites W2102443458 @default.
• W746630715 cites W2112535875 @default.
• W746630715 cites W2113122060 @default.
• W746630715 cites W2114282601 @default.
• W746630715 cites W2115954319 @default.
• W746630715 cites W2129949847 @default.
• W746630715 cites W2130177169 @default.
• W746630715 cites W2132310147 @default.
• W746630715 cites W2141337702 @default.
• W746630715 cites W2143645502 @default.
• W746630715 cites W2146573461 @default.
• W746630715 cites W2151010498 @default.
• W746630715 cites W2153525556 @default.
• W746630715 cites W2153826038 @default.
• W746630715 cites W2160333540 @default.
• W746630715 cites W2162653594 @default.
• W746630715 cites W2170000583 @default.
• W746630715 cites W2320288944 @default.
• W746630715 cites W2408051866 @default.
• W746630715 cites W1601050931 @default.
• W746630715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4466949" @default.
• W746630715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26097562" @default.
• W746630715 hasPublicationYear "2015" @default.
• W746630715 type Work @default.
• W746630715 sameAs 746630715 @default.
• W746630715 citedByCount "32" @default.
• W746630715 countsByYear W7466307152015 @default.
• W746630715 countsByYear W7466307152016 @default.
• W746630715 countsByYear W7466307152017 @default.
• W746630715 countsByYear W7466307152018 @default.
• W746630715 countsByYear W7466307152019 @default.
• W746630715 countsByYear W7466307152020 @default.
• W746630715 countsByYear W7466307152021 @default.
• W746630715 countsByYear W7466307152022 @default.
• W746630715 countsByYear W7466307152023 @default.
• W746630715 crossrefType "journal-article" @default.
• W746630715 hasAuthorship W746630715A5038829016 @default.
• W746630715 hasAuthorship W746630715A5049763932 @default.
• W746630715 hasAuthorship W746630715A5065771969 @default.
• W746630715 hasConcept C104317684 @default.
• W746630715 hasConcept C121608353 @default.
• W746630715 hasConcept C126322002 @default.
• W746630715 hasConcept C127561419 @default.
• W746630715 hasConcept C143998085 @default.
• W746630715 hasConcept C2776694085 @default.
• W746630715 hasConcept C2777394393 @default.
• W746630715 hasConcept C2778239845 @default.
• W746630715 hasConcept C2780427987 @default.
• W746630715 hasConcept C2781190966 @default.
• W746630715 hasConcept C2781451048 @default.
• W746630715 hasConcept C502942594 @default.
• W746630715 hasConcept C54355233 @default.
• W746630715 hasConcept C62203573 @default.
• W746630715 hasConcept C71924100 @default.
• W746630715 hasConcept C86803240 @default.
• W746630715 hasConcept C98274493 @default.
• W746630715 hasConceptScore W746630715C104317684 @default.
• W746630715 hasConceptScore W746630715C121608353 @default.
• W746630715 hasConceptScore W746630715C126322002 @default.
• W746630715 hasConceptScore W746630715C127561419 @default.
• W746630715 hasConceptScore W746630715C143998085 @default.
• W746630715 hasConceptScore W746630715C2776694085 @default.
• W746630715 hasConceptScore W746630715C2777394393 @default.
• W746630715 hasConceptScore W746630715C2778239845 @default.
• W746630715 hasConceptScore W746630715C2780427987 @default.
• W746630715 hasConceptScore W746630715C2781190966 @default.
• W746630715 hasConceptScore W746630715C2781451048 @default.
• W746630715 hasConceptScore W746630715C502942594 @default.
• W746630715 hasConceptScore W746630715C54355233 @default.
• W746630715 hasConceptScore W746630715C62203573 @default.
• W746630715 hasConceptScore W746630715C71924100 @default.
• W746630715 hasConceptScore W746630715C86803240 @default.
• W746630715 hasConceptScore W746630715C98274493 @default.
• W746630715 hasIssue "4" @default.
• W746630715 hasLocation W7466307151 @default.
• W746630715 hasOpenAccess W746630715 @default.
• W746630715 hasPrimaryLocation W7466307151 @default.
• W746630715 hasRelatedWork W110410993 @default.
• W746630715 hasRelatedWork W1975802428 @default.
• W746630715 hasRelatedWork W2006318969 @default.

• next