FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W747033493> ?p ?o ?g. }

• W747033493 endingPage "783" @default.
• W747033493 startingPage "781" @default.
• W747033493 abstract "Dear Editor: We would like to report an interesting case of a man suffering from both ulcerative colitis (UC) and toxic epidermal necrolysis (TEN) at the same time. We are aware that such cases are already described in medical literature. However, previous articles perceive TEN as an adverse effect of derivatives of 5-aminosalicyclic acid (5-ASA), which are the foundation of conservative management of UC. In our patient, UC was diagnosed postmortem so he did not receive any drugs for UC at the time his cutaneous symptoms appeared. We believe it to be the first report of such co-existence without involvement of 5-ASA. The described patient was a 49-year-old man with left kidney agenesia, suffering from type 2 diabetes and chronic constipation. Surgical history included appendectomy and laparotomy due to fecal obstruction of the sigmoid colon nine years before. His constant medications were as follows: acetylosalicylic acid 75 mg 1×, propranolol 40 mg 2×, glimepiride 4 mg 1×, metformin 1000 mg 3×, vinpocetine 10 mg 2×, piracetam 1200 mg 2×, and pridinol 5 mg 2×. In late 2012, he developed slowly expanding bullae. Ambulatory management with glucocorticoid (i.v./i.m. dexametasone 4 mg) was administered but unsuccessful. Due to unknown etiology of his condition and ineffectiveness of empiric treatment, he was admitted in early 2013 to the Department of Dermatology of Wroclaw Medical University (WMU). Upon admission, multiple small and large bullae filled with serous fluid were present on all of the patient’s skin. Mucosae were not affected. Since day one of hospitalization, the patient had no bowel movement. Series of laboratory, radiological, and pathomorphologic tests were performed. Laboratory tests revealed the following: (1) elevated inflammatory markers (WBC 28,400/μl, CRP 84.5 mg/l) and eosinophilia (11.2 %) in peripheral blood smear, (2) decreased level of total plasma protein (5.2 g/dl) and albumin (3.3 g/dl), (3) slightly decreased level of vitamin B12 and folic acid, but no anemia (RBC 5,670,000/μl, HGB 16.7 g/dl, HCT 46.6 %), (4) dyslipidemia (HDL cholesterol 23 mg/dl, triglycerides 240 mg/dl), and (5) bad metabolic control of diabetes (glycemia up to 459 mg/dl, HbA1C 7.1 %, glycosuria 500 mg/dl). Tumor markers (CA15-3, CA19-9, CEA, PSA, AFP, and CA125) as well as virusological studies were negative: anti-HBe (−), anti-HBs level normal, anti-HCV (−), and anti-HBc (+). Chest X-ray showed no abnormalities. Direct immunofluorescence (DIF) study of skin sample was performed. Linear concretions of C3c along the basement membrane zone (BMZ) and additionally sparse fine-grained concretions of IgM along BMZ were discovered. There were no IgG, IgA, or C1q concretions. The result of DIF study suggested the diagnosis of pemphigoid. Histopathological examination of skin sample was also performed. It revealed vast subepidermal bullae, which might have indicated pemphigoid. After diagnosing pemphigoid, systemic treatment with sulfone (dapsone 50 mg, than 100 mg daily) and i.v. glucocorticoid (methylprednisolone 250 mg—2 doses at the fifth and ninth day) as well as local dressings (sulfathiazole with silver, hydrocortisone, oxytetracycline) were applied. Painmanagement involved paracetamol and tramadol. Glycemia was controlled by metformin (1000 mg 3×) and glimepiride (4 mg); the latter was then switched to insulin (intermediate* Michal Aporowicz micapo@interia.pl" @default.
• W747033493 created "2016-06-24" @default.
• W747033493 creator A5024015514 @default.
• W747033493 creator A5042049532 @default.
• W747033493 date "2015-06-24" @default.
• W747033493 modified "2023-10-16" @default.
• W747033493 title "Toxic epidermal necrolysis co-existing with severe onset of ulcerative colitis—different condition or extraintestinal feature?—case report" @default.
• W747033493 doi "https://doi.org/10.1007/s00384-015-2285-8" @default.
• W747033493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4773502" @default.
• W747033493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26105743" @default.
• W747033493 hasPublicationYear "2015" @default.
• W747033493 type Work @default.
• W747033493 sameAs 747033493 @default.
• W747033493 citedByCount "0" @default.
• W747033493 crossrefType "journal-article" @default.
• W747033493 hasAuthorship W747033493A5024015514 @default.
• W747033493 hasAuthorship W747033493A5042049532 @default.
• W747033493 hasBestOaLocation W7470334931 @default.
• W747033493 hasConcept C126322002 @default.
• W747033493 hasConcept C138885662 @default.
• W747033493 hasConcept C16005928 @default.
• W747033493 hasConcept C2776401178 @default.
• W747033493 hasConcept C2779134260 @default.
• W747033493 hasConcept C2780479503 @default.
• W747033493 hasConcept C2780664588 @default.
• W747033493 hasConcept C41260117 @default.
• W747033493 hasConcept C41895202 @default.
• W747033493 hasConcept C71924100 @default.
• W747033493 hasConcept C90924648 @default.
• W747033493 hasConceptScore W747033493C126322002 @default.
• W747033493 hasConceptScore W747033493C138885662 @default.
• W747033493 hasConceptScore W747033493C16005928 @default.
• W747033493 hasConceptScore W747033493C2776401178 @default.
• W747033493 hasConceptScore W747033493C2779134260 @default.
• W747033493 hasConceptScore W747033493C2780479503 @default.
• W747033493 hasConceptScore W747033493C2780664588 @default.
• W747033493 hasConceptScore W747033493C41260117 @default.
• W747033493 hasConceptScore W747033493C41895202 @default.
• W747033493 hasConceptScore W747033493C71924100 @default.
• W747033493 hasConceptScore W747033493C90924648 @default.
• W747033493 hasIssue "3" @default.
• W747033493 hasLocation W7470334931 @default.
• W747033493 hasLocation W7470334932 @default.
• W747033493 hasLocation W7470334933 @default.
• W747033493 hasLocation W7470334934 @default.
• W747033493 hasOpenAccess W747033493 @default.
• W747033493 hasPrimaryLocation W7470334931 @default.
• W747033493 hasRelatedWork W1965557584 @default.
• W747033493 hasRelatedWork W1977849899 @default.
• W747033493 hasRelatedWork W1989738331 @default.
• W747033493 hasRelatedWork W2002078683 @default.
• W747033493 hasRelatedWork W2010229349 @default.
• W747033493 hasRelatedWork W2041879233 @default.
• W747033493 hasRelatedWork W2314423394 @default.
• W747033493 hasRelatedWork W2325410327 @default.
• W747033493 hasRelatedWork W3195223749 @default.
• W747033493 hasRelatedWork W4364361620 @default.
• W747033493 hasVolume "31" @default.
• W747033493 isParatext "false" @default.
• W747033493 isRetracted "false" @default.
• W747033493 magId "747033493" @default.
• W747033493 workType "article" @default.