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- W747097183 abstract "5142 It has been proposed that aging increases the development of cancer via modifications in tissue microenvironment. However, the mechanisms underlying this effect are poorly understood. In this study we compared the microenvironments of young and aged rat liver in their ability to support the clonal growth of transplanted normal hepatocytes. Young (3 months) and aged (18 months old) Fischer 344 rats were infused (via portal vein) with 2x10 6 hepatocytes isolated from a normal syngenic adult donor. Animals deficient in dipeptidyl-peptidase type IV (DPP-IV − ) enzyme were used as recipients, allowing for the histochemical detection of injected, DPP-IV + cells. Groups of animals were sacrificed 2 weeks, 3 and 6 months thereafter. Isolated DPP-IV + hepatocytes were integrated in the liver of both young and old rats killed at 2 weeks, with no intergroup differences. A significant expansion of donor-derived cells was observed in the liver of rats transplanted at old age: clusters comprising up to 20 DPP-IV + hepatocytes/cross section were present after 3 months and were further enlarged after 6 months (up to 120 cells/cluster/cross section). In striking contrast, no growth of DPP-IV + transplanted hepatocytes was present after either 3 or 6 months in the liver of rats transplanted at 3 months of age. These results indicate that the microenvironment of the aged liver supports the clonal expansion of transplanted normal hepatocytes. Such clonogenic potential could be exploited in the field of regenerative medicine. On the other hand, it may also contribute to the selective growth of altered cells during cancer development associated with aging. This work was supported in part by ROTRF grant 820172684 to E.L and by Italian Health Ministry." @default.
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- W747097183 date "2006-04-15" @default.
- W747097183 modified "2023-09-23" @default.
- W747097183 title "The microenvironment of the aged rat liver is clonogenic to normal transplanted hepatocytes." @default.
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