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- W74803352 abstract "Pharmaceutical companies’ research and development efforts range from understanding a disease to bringing safe and effective new drugs to market for patients with the disease. Research determines the basic causes of disease at the level of genes, proteins, and cells. This understanding provides targets for potential new drugs. Researchers validate these targets, discover the correct molecule (potential drug) to interact with the target chosen, test the new compound in the laboratory and clinic for safety and efficacy to gain approval for marketing, and finally provide the new drug to doctors for patient use. This process takes an average of 10–15 years and can cost more than US$1.2 billion. This number includes the cost of the thousands of failures. For every 5000–10 000 compounds that enter the research and development pipeline, ultimately only one receives approval. This chapter provides an overview of the drug development process." @default.
- W74803352 created "2016-06-24" @default.
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- W74803352 date "2013-01-01" @default.
- W74803352 modified "2023-09-24" @default.
- W74803352 title "Overview of the Role of Pathology in Product Discovery and Safety Assessment" @default.
- W74803352 doi "https://doi.org/10.1016/b978-0-12-415759-0.00022-4" @default.
- W74803352 hasPublicationYear "2013" @default.
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