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- W74808634 abstract "The mouse prostate has been the primary focus of research in regards to both normal stem cells and cancer stem cell-like cell populations in the animal prostate. The proximal region is the probable location of stem cells because it contains a high number of label-retaining cells, which express stem-cell specific markers, that are resistant to androgen ablation and have a greater capacity to regenerate prostate tissue in growth assays as compared to cells located in the distal regions. Stem cell growth assays include both in vivo and cell culture techniques. However, in vivo growth assays are better suited toward assessing full stem cell potential. Stem cells reside in a specialized microenvironment, in which their quiescence and proliferation is regulated by factors such as TGF-β, EGF, and IGF. Currently, two models of differentiation exist, the traditional linear model and the more recent branching differentiation model. Transgenic mice with activation or deficiency of genes such as androgen receptor, fibroblast growth factor 8, c-Myc, Akt, Pten, Nkx3.1, Rb, p53, Apc, or some of their combinations demonstrate gene-dependent development of the various stages of prostate cancer. Preliminary findings suggest that different genetic events have unequal transforming effects on stem cells and their progeny, and mouse models do have the potential to increase our understanding of the relevance of fundamental processes governing the control of stem cells to cancer. Additionally, they allow for the investigation of a stem cell-like cancer cell population, which may be responsible for maintaining growth after androgen ablation therapy." @default.
- W74808634 created "2016-06-24" @default.
- W74808634 creator A5009732429 @default.
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- W74808634 date "2009-01-01" @default.
- W74808634 modified "2023-09-25" @default.
- W74808634 title "Prostate Stem Cells and Cancer in Animals" @default.
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