Matches in SemOpenAlex for { <https://semopenalex.org/work/W74856030> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W74856030 endingPage "81" @default.
- W74856030 startingPage "77" @default.
- W74856030 abstract "We performed this study to determine the effect of extract of whole ginseng and ginsenosides (total saponin, panaxadiol and panaxatriol) on jejunal crypt survival, endogenous spleen colony formation, and apoptosis in jejunal crypt cells of mice irradiated with high- and low-doses of gamma-radiation. The radioprotective effect of ginseng was compared with the effect of diethyldithiocarbamate (DDC). The jejunal crypts were protected by pretreatment with extract of whole ginseng (i.p.: 50 mg/kg of body weight at 12 and 36 hours before irradiation, p < 0.005). Extract of whole ginseng (p < 0.005), total saponin (p < 0.01) or panaxadiol (p < 0.05) administration before irradiation (i.p.: 50 mg/kg of body weight at 12 and 36 hours before irradiation) resulted in an increase in the formation of the endogenous spleen colony. The frequency of radiation-induced apoptosis in the intestinal crypt cells was also reduced by pretreatment with extract of whole ginseng (p < 0.05), total saponin (p < 0.005) or panaxadiol (p < 0.05) (i.p. at 12 and 36 hours before irradiation). The radioprotective effect on the jejunal crypts and apoptosis in the DDC-treated group appeared similar to that in the ginseng-treated groups. Treatment with DDC showed no significant modifying effects on the formation of the endogenous spleen colony. In the experiment on the effect of ginsenosides, the result indicated that panaxadiol might have a major radioprotective effect. Although the mechanisms of this inhibitory effect remain to be elucidated, these results indicated that ginseng might be a useful radioprotector, especially since it is a relatively nontoxic natural product. Further studies are needed to better characterize the protective nature of ginseng extract and each ginsenoside." @default.
- W74856030 created "2016-06-24" @default.
- W74856030 creator A5053816682 @default.
- W74856030 creator A5058935068 @default.
- W74856030 creator A5069167592 @default.
- W74856030 date "2003-03-27" @default.
- W74856030 modified "2023-09-24" @default.
- W74856030 title "Modification of radiation response in mice by ginsenosides, active components of Panax ginseng." @default.
- W74856030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12655795" @default.
- W74856030 hasPublicationYear "2003" @default.
- W74856030 type Work @default.
- W74856030 sameAs 74856030 @default.
- W74856030 citedByCount "6" @default.
- W74856030 countsByYear W748560302012 @default.
- W74856030 countsByYear W748560302017 @default.
- W74856030 crossrefType "journal-article" @default.
- W74856030 hasAuthorship W74856030A5053816682 @default.
- W74856030 hasAuthorship W74856030A5058935068 @default.
- W74856030 hasAuthorship W74856030A5069167592 @default.
- W74856030 hasConcept C126322002 @default.
- W74856030 hasConcept C142724271 @default.
- W74856030 hasConcept C16613235 @default.
- W74856030 hasConcept C185592680 @default.
- W74856030 hasConcept C190283241 @default.
- W74856030 hasConcept C204787440 @default.
- W74856030 hasConcept C2776539398 @default.
- W74856030 hasConcept C2778564307 @default.
- W74856030 hasConcept C2778770856 @default.
- W74856030 hasConcept C2779232237 @default.
- W74856030 hasConcept C2780931953 @default.
- W74856030 hasConcept C55493867 @default.
- W74856030 hasConcept C66090201 @default.
- W74856030 hasConcept C71924100 @default.
- W74856030 hasConcept C98274493 @default.
- W74856030 hasConceptScore W74856030C126322002 @default.
- W74856030 hasConceptScore W74856030C142724271 @default.
- W74856030 hasConceptScore W74856030C16613235 @default.
- W74856030 hasConceptScore W74856030C185592680 @default.
- W74856030 hasConceptScore W74856030C190283241 @default.
- W74856030 hasConceptScore W74856030C204787440 @default.
- W74856030 hasConceptScore W74856030C2776539398 @default.
- W74856030 hasConceptScore W74856030C2778564307 @default.
- W74856030 hasConceptScore W74856030C2778770856 @default.
- W74856030 hasConceptScore W74856030C2779232237 @default.
- W74856030 hasConceptScore W74856030C2780931953 @default.
- W74856030 hasConceptScore W74856030C55493867 @default.
- W74856030 hasConceptScore W74856030C66090201 @default.
- W74856030 hasConceptScore W74856030C71924100 @default.
- W74856030 hasConceptScore W74856030C98274493 @default.
- W74856030 hasIssue "1" @default.
- W74856030 hasLocation W748560301 @default.
- W74856030 hasOpenAccess W74856030 @default.
- W74856030 hasPrimaryLocation W748560301 @default.
- W74856030 hasRelatedWork W1600302862 @default.
- W74856030 hasRelatedWork W2057400463 @default.
- W74856030 hasRelatedWork W2061378428 @default.
- W74856030 hasRelatedWork W2333010588 @default.
- W74856030 hasRelatedWork W2379107835 @default.
- W74856030 hasRelatedWork W2396391974 @default.
- W74856030 hasRelatedWork W2909861240 @default.
- W74856030 hasRelatedWork W2995316848 @default.
- W74856030 hasRelatedWork W74856030 @default.
- W74856030 hasRelatedWork W764423354 @default.
- W74856030 hasVolume "17" @default.
- W74856030 isParatext "false" @default.
- W74856030 isRetracted "false" @default.
- W74856030 magId "74856030" @default.
- W74856030 workType "article" @default.