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• W748842364 abstract "The epithelial layer of mucosal surfaces in the gastrointestinal tract is a busy surface for communication between the host and both commensal and pathogenic bacteria. In the case of invasive pathogens, the epithelium represents the major barrier that has to be overcome. Important virulence determinants include those mediating adhesion to and invasion of the epithelium. Different strategies are used to induce the uptake of invasive bacteria (Figure 8.1). For example, Yersinia spp. and Listeria monocytogenes express adhesins that bind tightly to host cell-surface proteins. This binding interaction initiates invasion by triggering signaling pathways normally involved in the regulation of cell adhesion. This invasion mechanism has been termed “zipper” because the host cell membrane is wrapped tightly around the bacteria (Mengaud et al., 1996). For more details on the zipper mechanism; see Alonso and Garcia-del Portillo (2004). More recently, a variant of this mechanism, termed the “tandem β-zipper,” has been identified. As an example of this entry mechanism, pathogenic bacteria like Staphylococcus aureus express surface proteins that bind to human fibronectin. This fibronectin coat facilitates binding to host cell-surface receptors and mediates invasion (Figure 8.1b) (Schwarz-Linek et al., 2004). A third strategy, termed “trigger mechanism,” is employed by Salmonella and Shigella spp. This involves specialized protein-transport systems called type III secretion systems (TTSS) to inject virulence factors (effector proteins) directly into the cytosol of the host cells. The translocated effector proteins trigger host signaling cascades that mediate a variety of responses, including pathogen uptake (Hueck, 1998)." @default.
• W748842364 created "2016-06-24" @default.
• W748842364 creator A5010604441 @default.
• W748842364 creator A5017081686 @default.
• W748842364 date "2006-09-07" @default.
• W748842364 modified "2023-09-27" @default.
• W748842364 title "Host-mediated invasion: theSalmonellaTyphimurium trigger" @default.
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